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Surgery is the main treatment, often combined with antibiotics. The prognosis is generally favorable, with minimal risk of lasting disability or recurrence. Brodie abscess is responsible for 2.5%-42% of primary bone infections. It is named after Sir Benjamin Collins Brodie, 1st Baronet, who initially described the condition in the 1830s.
Antibiotics by mouth and by intravenous appear similar. [32] [33] Due to insufficient evidence it is unclear what the best antibiotic treatment is for osteomyelitis in people with sickle cell disease as of 2019. [34] Initial first-line antibiotic choice is determined by the patient's history and regional differences in common infective organisms.
The veterinary uses of clindamycin are quite similar to its human indications, and include treatment of osteomyelitis, [74] skin infections, and toxoplasmosis, for which it is the preferred drug in dogs and cats. [75] They can be used both by mouth and topically. [62] A disadvantage is that bacterial resistance can develop fairly quickly. [62]
Flucloxacillin, also known as floxacillin, is an antibiotic used to treat skin infections, external ear infections, infections of leg ulcers, diabetic foot infections, and infection of bone. [6] It may be used together with other medications to treat pneumonia, and endocarditis. [6]
Severe infections typically require IV antibiotics that cover more pathogens, such as gram positive organisms, gram negative organisms, and obligate anaerobes to allow for better treatment outcomes. [4] Total antibiotic treatment of severe infections should be approximately 2–3 weeks or more, depending on how extensive the infection is. [5]
Anaerobes infections are often polymicrobial in nature, and sometimes (i.e. decubitus ulcers, diabetic foot ulcer) they are complicated by bacteremia and/or osteomyelitis. [41] Infections which are in the deep tissues (necrotizing cellulitis, fasciitis and myositis) often include Clostridium spp., S. pyogenes or polymicrobic combinations of ...
Most diabetic foot infections (DFIs) require treatment with systemic antibiotics. The choice of the initial antibiotic treatment depends on several factors such as the severity of the infection, whether the patient has received another antibiotic treatment for it, and whether the infection has been caused by a micro-organism that is known to be ...
Linezolid is an antibiotic used for the treatment of infections caused by Gram-positive bacteria that are resistant to other antibiotics. [9] [10] Linezolid is active against most Gram-positive bacteria that cause disease, including streptococci, vancomycin-resistant enterococci (VRE), and methicillin-resistant Staphylococcus aureus (MRSA).