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An enteric coating is a polymer barrier applied to oral medication that prevents its dissolution or disintegration in the gastric environment. [1] This helps by either protecting drugs from the acidity of the stomach, the stomach from the detrimental effects of the drug, or to release the drug after the stomach (usually in the upper tract of the intestine). [2]
Enteric coating on aspirin may be used in manufacturing to prevent release of aspirin into the stomach to reduce gastric harm, but enteric coating does not reduce gastrointestinal bleeding risk. [188] [189] Enteric-coated aspirin may not be as effective at reducing blood clot risk.
Additionally, aspirin induces the formation of NO-radicals in the body, which have been shown in mice to have an independent mechanism of reducing inflammation. This reduces leukocyte adhesion, which is an important step in immune response to infection. There is currently insufficient evidence to show that aspirin helps to fight infection. [18]
PPI exist in the forms of oral enteric coated tablets or enteric granules capped within capsules. To ensure the effectiveness of the medication, patients should swallow the whole tablet. [ 62 ] They should not chew or cut the tablets, nor open the capsule and grind the granules. [ 62 ]
Antacids would increase the pH environment in the stomach and cause premature release of enteric coated drugs, which are designed to be protected from an acidic environment in stomach. [21] For example, proton-pump inhibitors (PPIs) are enteric coated to protect them from decomposition under an acidic environment. [ 22 ]
Certain NSAIDs, such as aspirin, have been marketed in enteric-coated formulations that manufacturers claim reduce the incidence of gastrointestinal ADRs. Similarly, some believe that rectal formulations may reduce gastrointestinal ADRs.
A film coating is a thin polymer-based coat that is typically sprayed onto solid pharmaceutical dosage forms, such as tablets, capsules, pellets or granules.Film coating can impact both its appearance and its pharmacokinetics making it an essential process in making the final drug product.
enteric coating: ECC: endocervical curettage: ECD: endocardial cushion defect: ECF: extracellular fluid enteric cytopathic human orphan: ECG: electrocardiogram: ECM: extracellular matrix: ECHO: enteric cytopathic human orphan virus: ECI: febris e causa ignota (normally written as febris E.C.I.) fever of unknown origin ECLS: extracorporeal life ...