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Bioidentical hormones were first used for menopausal symptom relief in the 1930s, [2] after Canadian researcher James Collip developed a method to extract an orally active estrogen from the urine of pregnant women and marketed it as the active agent in a product called Emmenin. [3]
Estrogen and other hormones are given to postmenopausal women in order to prevent osteoporosis as well as treat the symptoms of menopause such as hot flashes, vaginal dryness, urinary stress incontinence, chilly sensations, dizziness, fatigue, irritability, and sweating. Fractures of the spine, wrist, and hips decrease by 50 to 70% and spinal ...
[9] [8] As such, it is an estrogen, or an agonist of the estrogen receptors. [8] [9] Estradiol acetate is of about 15% higher molecular weight than estradiol due to the presence of its C3 acetate ester. [3] Because estradiol acetate is a prodrug of estradiol, it is considered to be a natural and bioidentical form of estrogen. [9] [10]
Breast cancer was increased in women treated with estrogen and a progestin, but not with estrogen and progesterone or estrogen alone. Treatment with unopposed estrogen (i.e., an estrogen alone without a progestogen) is contraindicated if the uterus is still present, due to its proliferative effect on the endometrium. The WHI also found a ...
One potential risk is an increased chance of breast cancer. Some of the ingredients included in supplements are carcinogenic, including don quai. [1]: 1331 By altering the body's hormonal levels, certain ingredients, including zearalenone, may reduce fertility. [9] One ingredient, kava, may cause liver damage. [2]: 1347
"The primary treatment — and the first-line treatment — should be hormone (estrogen) therapy, especially for moderate-to-severe menopause symptoms," Dr. Anna Barbieri, assistant clinical ...
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