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Cycle (cyc) is a gene in Drosophila melanogaster that encodes the CYCLE protein (CYC). The Cycle gene ( c yc) is expressed in a variety of cell types in a circadian manner. It is involved in controlling both the sleep-wake cycle and circadian regulation of gene expression by promoting transcription in a negative feedback mechanism.
The fastest cycling mammalian cells in culture, crypt cells in the intestinal epithelium, have a cycle time as short as 9 to 10 hours. Stem cells in resting mouse skin may have a cycle time of more than 200 hours. Most of this difference is due to the varying length of G 1, the most variable phase of the cycle. M and S do not vary much.
Gene oscillations – some genes are expressed more during certain hours of the day than during other hours. Within each cycle, the time period during which the process is more active is called the acrophase. [4] When the process is less active, the cycle is in its bathyphase or trough phase.
8697 52563 Ensembl ENSG00000094880 ENSMUSG00000024370 UniProt Q9UJX2 Q8BGZ4 RefSeq (mRNA) NM_004661 NM_178347 RefSeq (protein) NP_004652 NP_848124 Location (UCSC) Chr 5: 138.19 – 138.21 Mb Chr 18: 34.76 – 34.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 ...
[12] [13] During the G1 phase of the cell cycle, Cdc6 is recruited by ORC to form a launching pad for the loading of two head-to-head Mcm2-7 hexamers, also known as the pre-replication complex (pre-RC). [14] There is genetic and biochemical evidence that the recruitment of the double hexamer may involve either one [15] or two [16] ORCs.
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs.
19355 Ensembl ENSG00000113456 ENSMUSG00000022248 UniProt O60671 Q9QWZ1 RefSeq (mRNA) NM_001033673 NM_002853 NM_133282 NM_133377 NM_001289447 NM_001289448 NM_011232 RefSeq (protein) NP_002844 NP_001276376 NP_001276377 NP_035362 Location (UCSC) Chr 5: 34.91 – 34.92 Mb Chr 15: 10.49 – 10.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cell cycle checkpoint protein RAD1 is a ...
The cell cycle is a cycle rather than a linear process because the two daughter cells produced repeat the cycle. This process contains two main phases, interphase , in which the cell grows and synthesizes a copy of its DNA, and the mitotic (M) phase, during which the cell separates its DNA and divides into two new daughter cells. [ 7 ]