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Vitamin B 12, also known as cobalamin, is a water-soluble vitamin involved in metabolism. [2] It is one of eight B vitamins. It is required by animals, which use it as a cofactor in DNA synthesis, and in both fatty acid and amino acid metabolism. [3]
[4]: 44 Vitamin B 12 is an essential water-soluble vitamin, the deficiency of which creates anemia (macrocytic anemia), decreased bone marrow cell production (anemia, pancytopenia), neurological problems, as well as metabolic issues (methylmalonyl-CoA acidosis). [4]: 50–51 Vitamin B 12 is therefore an important vitamin for the body to absorb.
Because vitamin B 12 absorption is a multistep process that involves the stomach, pancreas and small intestine, and is mediated by two carriers: Haptocorrin and intrinsic factor, and because Haptocorrin (transcobalamin I) binds to vitamin B 12, and Vitamin B 12 is acid-sensitive, when vitamin B 12 binds to Haptocorrin it can safely pass through ...
Aerobic pathway that requires oxygen and in which cobalt is inserted late in the pathway; [6] [7] found in Pseudomonas denitrificans and Rhodobacter capsulatus.; Anaerobic pathway in which cobalt insertion is the first committed step towards cobalamin synthesis; [8] [9] [10] found in Salmonella typhimurium, Bacillus megaterium, and Propionibacterium freudenreichii subsp. shermanii.
B12 is a crucial vitamin necessary for wellness, supporting energy production (aka metabolism), brain function, heart health and more. Does B12 help you lose weight?
Vitamin B 12 is a major dietary methyl donor, involved in the one-carbon cycle of metabolism and a recent genome-wide association (GWA) analysis showed that increased DNA methylation is associated with increased BMI in adults, [59] consequently a deficiency of vitamin B 12 may disrupt DNA methylation and increase non-communicable disease risk.
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