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Wilson's disease is a genetic disorder in which copper builds up inside the liver and other tissues. Dimercaprol is a copper chelating agent that has been approved by the FDA to treat Wilson's disease. [8] Dimercaprol also shows effectiveness against snakebite by potently antagonizing the activity of Zn 2+-dependent snake venom ...
The hydrochloride salt of TETA, referred to as trientine hydrochloride, is a chelating agent that is used to bind and remove copper in the body to treat Wilson's disease, particularly in those who are intolerant to penicillamine. [11] Some recommend trientine as first-line treatment, but experience with penicillamine is more extensive. [16]
DOTA is derived from the macrocycle known as cyclen.The four secondary amine groups are modified by replacement of the N-H centers with N-CH 2 CO 2 H groups. The resulting aminopolycarboxylic acid, upon ionization of the carboxylic acid groups, is a high affinity chelating agent for di- and trivalent cations.
A 2012 research review found that chelation wasn’t an effective treatment for autism, and children have died from receiving EDTA chelation therapy, according to the Centers for Disease Control ...
It is used as a chelating agent: In Wilson's disease, a rare genetic disorder of copper metabolism, penicillamine treatment relies on its binding to accumulated copper and elimination through urine. [4] Penicillamine was the second line treatment for arsenic poisoning, after dimercaprol (BAL). [5] It is no longer recommended. [6]
Like other complexing agents in the aminopolycarboxylic acid class, trisodium N-(1-carboxylatoethyl)iminodiacetate (α-ADA) finds due to its ability to form stable chelate complexes with polyvalent ions (in particular the water hardening agents Ca 2+ and Mg 2+, as well as transition and heavy metal ions such as Fe 3+, Mn 2+, Cu 2+, etc.) use in ...
Succimer is an isomer of 2,3-dimercaptosuccinic acid. 2,3-dimercaptosuccinic acid is the organosulfur compound with the formula HO 2 CCH(SH)CH(SH)CO 2 H. This colorless solid contains two carboxylic acid and two thiol groups, the latter being responsible for its mildly unpleasant odour.
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