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The Canadian formulation of Preparation H includes a yeast extract called Biodyne which was removed in 1995 from the formulation sold in the United States. This yeast extract was the primary ingredient of the original formulation by inventor George Sperti , [ 5 ] [ 6 ] and Pfizer believes that it removes wrinkles from skin and heals dry ...
George Speri Sperti (January 17, 1900, Covington, Kentucky – April 29, 1991, Cincinnati, Ohio) was an Italian-American who invented Preparation H hemorrhoid medication. He also invented the Sperti Ultraviolet Lamp, Aspercreme for pain relief, and KVa Power Meter. [1] [2] Sperti graduated from the University of Cincinnati in 1923. Shortly ...
Phenylephrine is a small-molecule compound with the molecular formula C 9 H 13 NO 2 and a molecular weight of 167.205 g/mol. [57] [3] It is a highly hydrophilic compound, with an experimental log P of -0.3. [58] [57] [3] Phenylephrine is used medically almost always as the hydrochloride salt.
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Formulation studies involve developing a preparation of the drug which is both stable and acceptable to the patients. For orally administered drugs, this usually involves incorporating the drug into a tablet or a capsule. It is important to make the distinction that a tablet contains a variety of other potentially inert substances apart from ...
The formulation and manufacturing processes of topical gels are relatively simpler and more cost effective than other semisolid dosage forms. [ 5 ] [ 1 ] [ 8 ] The release profile of the gel can be modified by altering the properties of the gelator, allowing for continuous drug delivery. [ 1 ]
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