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Phytophotodermatitis, also known as berloque dermatitis, [1] [2] [3] margarita photodermatitis, [4] [5] lime disease [6] or lime phytodermatitis [6] is a cutaneous phototoxic inflammatory reaction resulting from contact with a light-sensitizing botanical agent (such as lime juice) followed by exposure to ultraviolet A (UV-A) light (from the sun, for instance).
Photodermatitis, sometimes referred to as sun poisoning or photoallergy, is a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure.
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People can also get rashes or burns after taking certain medications — such as common blood pressure medications — and being out in the sun. In those cases, the rash would appear on parts of ...
That's for old people.'" While skin cancers generally develop after 10 years of sun exposure, Robinson says she's treated patients as young as 15 years old for melanoma - a deadly form of skin cancer.
Artificial UV light sources from tanning units and phototherapy treatment units can also trigger PLE. About three-quarters of patients acquire PLE after UV-A exposure only, one-tenth after UV-B exposure only, and the rest after a combination of UV-A and UV-B exposure. [6] People vary in the amount of sun exposure needed to trigger the rash. [15]
The test compares the cytotoxic effect of a test substance when tested after the exposure, then tested in the absence of exposure to a non-cytotoxic dose of UVA/vis light. Cytotoxicity is expressed as a concentration-dependent reduction of the uptake of the vital dye - Neutral Red .
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