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The middle cerebral artery (MCA) is one of the three major paired cerebral arteries that supply blood to the cerebrum.The MCA arises from the internal carotid artery and continues into the lateral sulcus where it then branches and projects to many parts of the lateral cerebral cortex.
Middle cerebral artery syndrome is a condition whereby the blood supply from the middle cerebral artery (MCA) is restricted, leading to a reduction of the function of the portions of the brain supplied by that vessel: the lateral aspects of frontal, temporal and parietal lobes, the corona radiata, globus pallidus, caudate and putamen.
The dense MCA sign is caused by a fresh thrombus or embolus occluding the lumen of the middle cerebral artery. A thrombus with a high concentration of red blood cells and fibrin has increased density relative to normal flowing blood, leading to its hyperattenuating appearance on a non-contrast CT scan.
Identification of the dense artery sign is often based on subjective interpretation and false positives may occur. One study aiming to define criteria for the sign determined that measuring Hounsfield units on the CT scan could differentiate between the dense MCA sign associated with ischemic stroke and that caused by false positives. [8]
The right and left posterior cerebral arteries arise from the basilar artery, which is formed by the left and right vertebral arteries. The vertebral arteries arise from the subclavian arteries. The anterior communicating artery connects the two anterior cerebral arteries and could be said to arise from either the left or right side.
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On the right side it starts from the brachiocephalic artery (a branch of the aorta), and on the left side the artery comes directly off the aortic arch. At the throat it forks into the internal carotid artery and the external carotid artery. The internal carotid artery supplies the brain, and the external carotid artery supplies the face.
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