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Daniel Pearl (October 10, 1963 – February 1, 2002) was an American journalist who worked for The Wall Street Journal. On January 23, 2002, he was kidnapped by Islamist militants while he was on his way to what he had expected would be an interview with Pakistani religious cleric Mubarak Ali Gilani in the city of Karachi.
The more common side effects include fever, gastrointestinal disturbances, rashes, and immunological reactions. Taking rifampicin usually causes certain bodily fluids, such as urine, sweat, and tears, to become orange-red in color, a benign side effect that nonetheless can be frightening if it is not expected.
Isoniazid/rifampicin, also known as isoniazid/rifampin, is a medication used to treat tuberculosis. [1] It is a fixed dose combination of isoniazid and rifampicin (rifampin). [1] It is used together with other antituberculosis medication. [1] It is taken by mouth. [1] It is on the World Health Organization's List of Essential Medicines. [2]
Side effects are those of the underlying medications. [1] These may include poor coordination, loss of appetite, nausea, joint pain, feeling tired, and numbness. [2] Severe side effects include liver problems. [3] Use in those under the age of 15 may not be appropriate. [3] It is unclear if use in pregnancy is safe for the baby. [3]
In non-resistant TB, rifampin binds the beta subunit of RNA polymerase and disrupts transcription elongation. Mutation in the rpoB gene changes the sequence of amino acids and eventual conformation, or arrangement, of the beta subunit. In this case, rifampin can no longer bind or prevent transcription, and the bacterium is resistant. [19] [20]
Common side effects include abdominal pain, diarrhea, itchiness, dry skin, and change in skin color. [1] It can also cause swelling of the lining of the gastrointestinal tract, increased blood sugar, and sensitivity to the sun. [2] It is unclear if use during pregnancy is safe. [1]
Common side effects include nausea and loss of appetite. [5] Other side effects include liver inflammation, methemoglobinemia, [6] and a number of types of skin rashes. [3] While the safety of use during pregnancy is not entirely clear some physicians recommend that it be continued in those with leprosy. [3] It is of the sulfone class. [3]
Possible side effects include itchiness and skin rash, [5] and in rare cases hearing loss. [5] It is relatively broad spectrum, being effective against both Gram-negative and Gram-positive bacteria. [2] The combination is available over the counter in the US and Canada. [5]