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Ketamine and biological targets (with K i below 100 μM) Site Value Type Action Species Ref NMDA Tooltip N-Methyl-D-aspartate receptor: 0.25–0.66: K i: Antagonist: Human [101] [102] MOR Tooltip μ-Opioid receptor: 42: K i: Antagonist: Human [103] MOR 2 Tooltip μ-Opioid receptor: 12.1 K i: Antagonist: Human [104] KOR Tooltip κ-Opioid ...
It is given by slow injection into a vein or by mouth. [4] Side effects may include heart problems if given too quickly by injection into a vein. [4] By mouth it can result in abdominal pain, peptic ulcer disease, or gastrointestinal bleeding. [4] Greater care is recommended in those with kidney problems. [2]
K 1 is a polycyclic aromatic ketone, based on 2-methyl-1,4-naphthoquinone, with a 3-phytyl substituent. It is found naturally in a wide variety of green plants, particularly in leaves, since it functions as an electron acceptor during photosynthesis , forming part of the electron transport chain of photosystem I .
The closest method to IV/overall injection use, in terms of rapid onset, optimal bioavailability, and reduced health risks for most drugs, tends to be rectal administration via concentrated liquid solution (also known as a suppository), usually consisting of only ~1-3ml of liquid (typically not exceeding 5-10ml) assuming the drug in question ...
Spice is not specifically prohibited in Canada, but synthetic cannabis mimics are listed as a schedule II drug. Schedule II to the Controlled Drugs and Substances Act makes reference to specific synthetic compounds JWH-XXX and AM-XXXX, although is not limiting to those identified. [154] [155] Health Canada is debating the subject.
The Washington Post argued that the benefits of gender-transition for minors have not been completely proven scientifically despite controversy. Washington Post admits science behind puberty ...
Speedball, powerball, or over and under [1] is the polydrug mixture of a stimulant with a depressant, usually an opioid.The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, amphetamines can also be mixed with morphine and/or fentanyl.
Add solar superflares to the list of natural disasters of concern. Superflares are extremely strong solar flares – explosions with energies up to ten thousand times that of typical solar flares.