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Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma, which is a type of cancer of the immune system. Unlike most non-Hodgkin lymphomas (which are generally B-cell-related), CTCL is caused by a mutation of T cells. The cancerous T cells in the body initially migrate to the skin, causing various lesions to appear.
Lymphoma may present with certain nonspecific symptoms; if the symptoms are persistent, an evaluation to determine their cause, including possible lymphoma, should be undertaken. Lymphadenopathy [ 19 ] [ 20 ] or swelling of lymph nodes, is the primary presentation in lymphoma.
Primary cutaneous diffuse large B-cell lymphoma, leg type is an aggressive B-cell lymphoma that is often resistant to therapy and carries a poor prognosis, [5] i.e., they have a 5-year disease-specific survival rate of 43% or 70% depending on whether their cancer cells have or do not have, respectively, inactivating mutations in both of their ...
Other symptoms to note: Drug rashes can be a side effect of or a reaction to a new medication; almost any medication can cause a drug rash, but antibiotics and NSAIDs are the most common culprits ...
Psoriasis rashes typically go through cyclical periods of flare-ups, which can last for weeks or months, the Mayo Clinic says. Other symptoms: In addition to the skin, psoriasis can sometimes also ...
Subcutaneous panniculitis-like T-cell lymphoma is a rare type of lymphoma that infiltrates the subcutaneous fat but does not involve the skin. There are two subtypes – alpha-beta and gamma-delta. Patients with the gamma-delta subtype have a more aggressive clinical course. [3] It is described as CD3+/CD4-/CD8+, with CD30 and CD56 usually ...
Extranodal symptoms are symptoms shown by organs or tissues outside of the lymphatic system. Examples of such signs and symptoms include splenomegaly, abdominal pain and skin rash. Other common symptoms are fever, night sweat and unexplained weight loss. [2] These symptoms are collectively called B symptoms. Mature T-cell lymphoma is fast ...
The high cure rates and long survival of many people with Hodgkin lymphoma has led to a high concern with late adverse effects of treatment, including cardiovascular disease and second malignancies such as acute leukemias, lymphomas, and solid tumors within the radiation therapy field. Most people with early-stage disease are now treated with ...
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