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The hippocampus is located in the medial temporal lobe (subcortical), and is an infolding of the medial temporal cortex. [1] The hippocampus plays an important role in the transfer of information from short-term memory to long-term memory during encoding and retrieval stages. These stages do not need to occur successively, but are, as studies ...
Activation in the hippocampal region associated with episodic memory encoding has been shown to occur in the rostral portion of the region whereas activation associated with episodic memory retrieval occurs in the caudal portions. [20] This is referred to as the Hippocampal memory encoding and retrieval model or HIPER model.
Located above the hippocampus in the medial temporal lobes are two amygdalae (singular "amygdala"). The amygdalae are associated with both emotional learning and memory, as it responds strongly to emotional stimuli, especially fear. These neurons assist in encoding emotional memories and enhancing them.
This is complicated by the fact that the hippocampus is constantly involved in the encoding of new events and activation due to this fact is hard to separate using baseline measures. [21] Because of this, activation of the hippocampus during retrieval of distant memories may simply be a by-product of the subject encoding the study as an event. [21]
The hippocampus plays important roles in the consolidation of information from short-term memory to long-term memory, and in spatial memory that enables navigation. In humans, and other primates the hippocampus is located in the archicortex , one of the three regions of allocortex , in each hemisphere with neural projections to the neocortex .
Neuroscience acknowledges the existence of many types of memory and their physical location within the brain is likely to be dependent on the respective system mediating the encoding of this memory. [9] Such brain parts as the cerebellum, striatum, cerebral cortex, hippocampus, and amygdala are thought to play an important role in memory.
The parahippocampal gyrus (or hippocampal gyrus [1]) is a grey matter cortical region of the brain that surrounds the hippocampus and is part of the limbic system. The region plays an important role in memory encoding and retrieval. It has been involved in some cases of hippocampal sclerosis. [2] Asymmetry has been observed in schizophrenia. [3]
CA3 has been implicated in a number of working theories on memory and hippocampal learning processes. Slow oscillatory rhythms (theta-band; 3–8 Hz) are cholinergically driven patterns that depend on coupling of interneurons and pyramidal cell axons via gap junctions, as well as glutaminergic (excitatory) and GABAergic (inhibitory) synapses.