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2. Hyperuricemia - Wikipedia

   en.wikipedia.org/wiki/Hyperuricemia

   Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [5] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...

3. Your Gout Guide: From Symptoms to Treatment - AOL

   www.aol.com/gout-guide-symptoms-treatment...

   Having high levels of uric acid in the body can cause gout in the feet or other lower-body joints. ... Some things are known to increase the risk for gout. These are called risk factors.

4. Gout - Wikipedia

   en.wikipedia.org/wiki/Gout

   An evolutionary loss of urate oxidase (uricase), which breaks down uric acid, in humans and higher primates has made this condition common. [5] The triggers for precipitation of uric acid are not well understood. While it may crystallize at normal levels, it is more likely to do so as levels increase.

5. Uric acid - Wikipedia

   en.wikipedia.org/wiki/Uric_acid

   Uric acid displays lactam–lactim tautomerism. [4] Uric acid crystallizes in the lactam form, [5] with computational chemistry also indicating that tautomer to be the most stable. [6] Uric acid is a diprotic acid with pK a1 = 5.4 and pK a2 = 10.3. [7] At physiological pH, urate predominates in solution. [medical citation needed]

6. Dr. David Perlmutter’s ‘Drop Acid’ Book Shares Truth About ...

   www.aol.com/entertainment/dr-david-perlmutter...

   Drop Acid, which will be released on February 15, 2022, is an informative read for anyone looking to learn more about the truth about uric acid and its long-term effects on the human body. Show ...

7. Hypoxanthine-guanine phosphoribosyltransferase - Wikipedia

   en.wikipedia.org/wiki/Hypoxanthine-guanine...

   Mutations in the gene lead to hyperuricemia.At least 67 disease-causing mutations in this gene have been discovered: [5] Some men have partial (up to 20% less activity of the enzyme) HGPRT deficiency that causes high levels of uric acid in the blood, which leads to the development of gouty arthritis and the formation of uric acid stones in the urinary tract.

8. What Happens to Your Body When You Have Acid Reflux - AOL

   www.aol.com/lifestyle/happens-body-acid-reflux...

   Causes of Acid Reflux. Acid reflux may have several causes, especially certain foods, says Kansas-based registered dietitian Cheryl Mussatto, M.S., RD, LD. While everyone has different triggers ...

9. Purine metabolism - Wikipedia

   en.wikipedia.org/wiki/Purine_metabolism

   Methotrexate also indirectly inhibits purine synthesis by blocking the metabolism of folic acid (it is an inhibitor of the dihydrofolate reductase). Allopurinol is a drug that inhibits the enzyme xanthine oxidoreductase and, thus, lowers the level of uric acid in the body. This may be useful in the treatment of gout, which is a disease caused ...