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Primary biliary cholangitis (PBC), previously known as primary biliary cirrhosis, is an autoimmune disease of the liver. [1] [2] [3] It results from a slow, progressive destruction of the small bile ducts of the liver, causing bile and other toxins to build up in the liver, a condition called cholestasis.
The first symptoms typically include fever, intermittent abdominal pain, and an enlarged liver.Occasionally, yellow discoloration of the skin occurs. [4] Caroli disease usually occurs in the presence of other diseases, such as autosomal recessive polycystic kidney disease, cholangitis, gallstones, biliary abscess, sepsis, liver cirrhosis, kidney failure, and cholangiocarcinoma (7% affected). [2]
Choledocholithiasis (stones in common bile duct) is one of the complications of cholelithiasis (gallstones), so the initial step is to confirm the diagnosis of cholelithiasis. Patients with cholelithiasis typically present with pain in the right-upper quadrant of the abdomen with the associated symptoms of nausea and vomiting, especially after ...
Without appropriate treatment, recurrent episodes of cholecystitis are common. [1] Complications of acute cholecystitis include gallstone pancreatitis, common bile duct stones, or inflammation of the common bile duct. [1] [8] More than 90% of the time acute cholecystitis is caused from blockage of the cystic duct by a gallstone. [1]
Secondary extra-hepatic disorders involve organs excluding the liver. When a tumour develops at the pancreas head or bile duct, the common bile duct is compressed, opposing bile flow, eventually leading to hyperbilirubinemia. [4] Gallbladder carcinoma displays enlarged liver with Courvoisier's sign, a mass in the liver's right-upper quadrant. [27]
Gallbladder diseases are diseases involving the gallbladder and is closely linked to biliary disease, with the most common cause being gallstones (cholelithiasis). [1] [2]The gallbladder is designed to aid in the digestion of fats by concentrating and storing the bile made in the liver and transferring it through the biliary tract to the digestive system through bile ducts that connect the ...
First lines of treatment can include mass spectrum antibiotics or drainage of the bile duct that is infected followed by close monitoring. [7] Endoscopic surgery is favored over open procedures to reduce infection and quicker recovery times. If these fail a liver transplant may be necessary. [citation needed]
Bile duct hamartoma or biliary hamartoma, are benign lesions of the intrahepatic bile duct. [1] They are classically associated with polycystic liver disease , as may be seen in the context of polycystic kidney disease , and represent a malformation of the liver plate.