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  2. Replication crisis - Wikipedia

    en.wikipedia.org/wiki/Replication_crisis

    Replication has been called "the cornerstone of science". [9] [10] Environmental health scientist Stefan Schmidt began a 2009 review with this description of replication: Replication is one of the central issues in any empirical science. To confirm results or hypotheses by a repetition procedure is at the basis of any scientific conception.

  3. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    The replication fork is a structure that forms within the long helical DNA during DNA replication. It is produced by enzymes called helicases that break the hydrogen bonds that hold the DNA strands together in a helix. The resulting structure has two branching "prongs", each one made up of a single strand of DNA.

  4. Replication timing - Wikipedia

    en.wikipedia.org/wiki/Replication_timing

    The temporal order of replication of all the segments in the genome, called its replication-timing program, can now be easily measured in two different ways. [1] One way simply measures the amount of the different DNA sequences along the length of the chromosome per cell.

  5. Hayflick limit - Wikipedia

    en.wikipedia.org/wiki/Hayflick_limit

    The typical normal human fetal cell will divide between 50 and 70 times before experiencing senescence. As the cell divides, the telomeres on the ends of chromosomes shorten. The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence.

  6. Reproducibility - Wikipedia

    en.wikipedia.org/wiki/Reproducibility

    Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.

  7. DNA re-replication - Wikipedia

    en.wikipedia.org/wiki/DNA_re-replication

    Replication of DNA always begins at an origin of replication. In yeast, the origins contain autonomously replicating sequences (ARS), distributed throughout the chromosome about 30 kb from each other. They allow replication of DNA wherever they are placed. Each one is 100-200 bp long, and the A element is one of the most conserved stretches.

  8. Replication - Wikipedia

    en.wikipedia.org/wiki/Replication

    Replication crisis; Self-replication, the process in which an entity (a cell, virus, program, etc.) makes a copy of itself DNA replication or DNA synthesis, the process of copying a double-stranded DNA molecule Semiconservative replication, mechanism of DNA replication; Viral replication, the process by which viruses produce copies of themselves

  9. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    Eukaryotic DNA replication is a conserved mechanism that restricts ... DNA polymerase will synthesize short fragments of DNA called Okazaki fragments which are added ...