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Replication has been called "the cornerstone of science". [9] [10] Environmental health scientist Stefan Schmidt began a 2009 review with this description of replication: Replication is one of the central issues in any empirical science. To confirm results or hypotheses by a repetition procedure is at the basis of any scientific conception.
The replication fork is a structure that forms within the long helical DNA during DNA replication. It is produced by enzymes called helicases that break the hydrogen bonds that hold the DNA strands together in a helix. The resulting structure has two branching "prongs", each one made up of a single strand of DNA.
The temporal order of replication of all the segments in the genome, called its replication-timing program, can now be easily measured in two different ways. [1] One way simply measures the amount of the different DNA sequences along the length of the chromosome per cell.
The typical normal human fetal cell will divide between 50 and 70 times before experiencing senescence. As the cell divides, the telomeres on the ends of chromosomes shorten. The Hayflick limit is the limit on cell replication imposed by the shortening of telomeres with each division. This end stage is known as cellular senescence.
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
Replication of DNA always begins at an origin of replication. In yeast, the origins contain autonomously replicating sequences (ARS), distributed throughout the chromosome about 30 kb from each other. They allow replication of DNA wherever they are placed. Each one is 100-200 bp long, and the A element is one of the most conserved stretches.
Replication crisis; Self-replication, the process in which an entity (a cell, virus, program, etc.) makes a copy of itself DNA replication or DNA synthesis, the process of copying a double-stranded DNA molecule Semiconservative replication, mechanism of DNA replication; Viral replication, the process by which viruses produce copies of themselves
Eukaryotic DNA replication is a conserved mechanism that restricts ... DNA polymerase will synthesize short fragments of DNA called Okazaki fragments which are added ...