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Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
Replication of DNA always begins at an origin of replication. In yeast, the origins contain autonomously replicating sequences (ARS), distributed throughout the chromosome about 30 kb from each other. They allow replication of DNA wherever they are placed. Each one is 100-200 bp long, and the A element is one of the most conserved stretches.
An investigation of replication rates in psychology in 2012 indicated higher success rates of replication in replication studies when there was author overlap with the original authors of a study [224] (91.7% successful replication rates in studies with author overlap compared to 64.6% successful replication rates without author overlap).
DNA damages cause changes in the structure of the genetic material and prevents the replication mechanism from functioning and performing properly. [1] The DNA damage response (DDR) is a complex signal transduction pathway which recognizes when DNA is damaged and initiates the cellular response to the damage.
Replication in prokaryotes occurs inside of the cytoplasm, and this all begins the replication that is formed of about 100 to 200 or more nucleotides. Eukaryotic DNA molecules have a significantly larger number of replicons , about 50,000 or more; however, replication does not occur at the same time on all of the replicons.
Frugality Fails: 10 Money-Saving Attempts That Could Backfire. clara.stratford@clearlink.com (Clara Stratford) December 20, 2024 at 1:41 PM.
Slipped strand mispairing (SSM, also known as replication slippage) is a mutation process which occurs during DNA replication. It involves denaturation and displacement of the DNA strands, resulting in mispairing of the complementary bases. Slipped strand mispairing is one explanation for the origin and evolution of repetitive DNA sequences. [1]
Image credits: rakennus_mokat To better understand how these mishaps happen and their real-world impact, we spoke with Rahul Mishra, a seasoned construction supervisor with 20 years of experience.