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An investigation of replication rates in psychology in 2012 indicated higher success rates of replication in replication studies when there was author overlap with the original authors of a study [224] (91.7% successful replication rates in studies with author overlap compared to 64.6% successful replication rates without author overlap).
In eukaryotes, the cell cycle consists of four main stages: G 1, during which a cell is metabolically active and continuously grows; S phase, during which DNA replication takes place; G 2, during which cell growth continues and the cell synthesizes various proteins in preparation for division; and the M phase, during which the duplicated ...
The mechanism by which this damage occurs is still not known. One possibility is that reduced origin activation leads to incomplete DNA replication. Significant re-replication is only observed when all CDK regulatory pathways are inhibited. [25] In mammalian cells, Cdt1 and Cdc6 are much more important to re-replication regulation. [25]
Reproducibility, closely related to replicability and repeatability, is a major principle underpinning the scientific method.For the findings of a study to be reproducible means that results obtained by an experiment or an observational study or in a statistical analysis of a data set should be achieved again with a high degree of reliability when the study is replicated.
Progress of replication forks is inhibited by many factors; collision with proteins or with complexes binding strongly on DNA, deficiency of dNTPs, nicks on template DNAs and so on. If replication forks get stuck and the rest of the sequences from the stuck forks are not copied, then the daughter strands get nick nick unreplicated sites.
The replication of DNA with a broken sugar-phosphate backbone is most likely facilitated by the homologous recombination proteins that confer resistance to ionizing radiation. The activity of PRR enzymes is regulated by the SOS response in bacteria and may be controlled by the postreplication checkpoint response in eukaryotes.
Another intriguing aspect of replication timing is that the temporal order of replication is disrupted in most cancers and in many diseases. [18] We do not yet understand the mechanisms behind this link, but it suggests that further research may reveal replication-timing changes as useful biomarkers for such diseases.
Example of direct replication and conceptual replication. There are two main types of replication in statistics. First, there is a type called “exact replication” (also called "direct replication"), which involves repeating the study as closely as possible to the original to see whether the original results can be precisely reproduced. [3]