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Estradiol cypionate (Depo-Estradiol, Estradiol Cypionate) – 5 mg/mL (1 mg/mL and 3 mg/mL discontinued) Estradiol valerate (Delestrogen, Estradiol Valerate) – 10 mg/mL, 20 mg/mL, 40 mg/mL Polyestradiol phosphate (Estradurin) was previously available in the U.S. but was discontinued.
Estradiol cypionate (EC), sold under the brand name Depo-Estradiol among others, is an estrogen medication which is used in hormone therapy for menopausal symptoms and low estrogen levels in women, in hormone therapy for trans women, and in hormonal birth control for women.
Most combined oral contraceptives contain ethinylestradiol or its prodrug mestranol as the estrogen component, but a few contain estradiol or estradiol valerate. Ethinylestradiol is generally used in oral contraceptives instead of estradiol because it has superior oral pharmacokinetics (higher bioavailability and less interindividual ...
Estradiol, mainly as esters including estradiol valerate, estradiol cypionate, and estradiol enanthate, is also the exclusive estrogen used in combined injectable contraceptives. [6] As of 2021, more than 95% of prescriptions are for combined hormonal birth control forms containing the synthetic estrogen ethinylestradiol (EE). [7]
Estradiol valerate/megestrol acetate; Estradiol valerate/methenmadinone caproate (Lutofollin) Polyestradiol phosphate/medroxyprogesterone acetate; Additional preparations listed at Combined injectable birth control § Research; For other indications: Estradiol valerate/gestonorone caproate (SH-834, SH-8.0834)
Oral estradiol valerate is used primarily in Europe, under the brand name Progynova. [152] Although oral estradiol valerate was previously available in the United States, [24] it is no longer available in this country except in combination with dienogest as a combined oral contraceptive (under the brand name Natazia). [39]
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