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For example, diabetes can cause intestinal neuropathy, pancreatitis leading to pancreatic insufficiency can impair digestive enzyme production, and bile may be affected as part of cirrhosis of the liver. [24] The use of proton pump inhibitors, a class of medication used to reduce stomach acid, is associated with an increased risk of developing ...
Intestinal pseudo-obstruction (IPO) is a clinical syndrome caused by severe impairment in the ability of the intestines to push food through. It is characterized by the signs and symptoms of intestinal obstruction without any lesion in the intestinal lumen. [ 1 ]
Acute pancreatitis typically presents with severe to extreme abdominal pain. [8] [35] While the mildest cases of pancreatitis may be managed exclusively with NSAIDs (which are preferred in such scenarios due to the anti-inflammatory effects and the better safety profile), most patients with pancreatitis require heavy opioid regimens for pain ...
Possible causes include exocrine pancreatic insufficiency, with poor digestion from lack of lipases, loss of bile salts, which reduces micelle formation, and small intestinal disease-producing malabsorption. Various other causes include certain medicines that block fat absorption or indigestible or excess oil/fat in diet.
Acute pancreatitis (AP) is a sudden inflammation of the pancreas.Causes include a gallstone impacted in the common bile duct or the pancreatic duct, heavy alcohol use, systemic disease, trauma, elevated calcium levels, hypertriglyceridemia (with triglycerides usually being very elevated, over 1000 mg/dL), certain medications, hereditary causes and, in children, mumps.
Pancreatic enzymes have been used as medications since at least the 1800s. [7] They are on the World Health Organization's List of Essential Medicines. [8] In 2022, it was the 253rd most commonly prescribed medication in the United States, with more than 1 million prescriptions. [9] [10]
Most of these medications are benzimidazole derivatives, related to omeprazole, but imidazopyridine derivatives such as tenatoprazole have also been developed. [77] Potassium-competitive inhibitors such as revaprazan reversibly block the potassium-binding site of the proton pump, acting more quickly, but are not available in most countries.
Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease. [1] It is generally used for mildly to moderately severe disease. [ 1 ]