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Volume of distribution may be increased by kidney failure (due to fluid retention) and liver failure (due to altered body fluid and plasma protein binding). Conversely it may be decreased in dehydration. The initial volume of distribution describes blood concentrations prior to attaining the apparent volume of distribution and uses the same ...
Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of a drug from one location to another within the body. Once a drug enters into systemic circulation by absorption or direct administration, it must be distributed into interstitial and intracellular fluids.
The Relative Span Factor (RSF) reduces the distribution to a single number. The parameter indicates the uniformity of the drop size distribution. The closer this number is to 1, the more uniform the spray will be (i.e. tightest distribution, smallest variance from the maximum drop size, Dmax, to the minimum drop size, Dmin ).
[7] [8] [9] Because of inertial effects, the fluid will prefer to the straight direction. Thus the flow rate of the straight pipe is greater than that of the vertical one. Furthermore, because the lower energy fluid in the boundary layer branches through the channels the higher energy fluid in the pipe centre remains in the pipe as shown in Fig. 4.
The classical and most reliable method of log P determination is the shake-flask method, which consists of dissolving some of the solute in question in a volume of octanol and water, then measuring the concentration of the solute in each solvent. [38] [39] The most common method of measuring the distribution of the solute is by UV/VIS ...
The intrinsic permeability is the attribute primarily influenced by the pore structure, and the fundamental physical factors governing fluid flow and distribution are the grain surface-to-volume ratio and grain shape. [6] The idea that the pore space is made up of a network of channels through which fluid can flow is particularly helpful. Pore ...
The conservation laws may be applied to a region of the flow called a control volume. A control volume is a discrete volume in space through which fluid is assumed to flow. The integral formulations of the conservation laws are used to describe the change of mass, momentum, or energy within the control volume.
Specific volume is the volume occupied by a unit of mass of a material. [1] In many cases, the specific volume is a useful quantity to determine because, as an intensive property, it can be used to determine the complete state of a system in conjunction with another independent intensive variable. The specific volume also allows systems to be ...