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Enfortumab vedotin, sold under the brand name Padcev, is an antibody-drug conjugate [6] used for the treatment of urothelial cancer. [4] [7] It is a nectin-4-directed antibody and microtubule inhibitor conjugate. [4] [7] Enfortumab refers to the monoclonal antibody part, and vedotin refers to the payload drug (MMAE) and the linker. [5]
Seattle Genetics (SGEN) and Astellas' enfortumab vedotin in combination with Merck's Keytruda proves safety in a phase I study as a first-line treatment for advanced bladder cancer. Shares up.
The FDA accepts Seattle Genetics (SGEN) and Astellas' BLA for enfortumab vedotin under a priority review to treat advanced/metastatic urothelial cancer. A verdict is pending on Mar 15, 2020.
Bladder cancer is the abnormal growth of cells on the bladder. These cells, ... followed by the antibody drug conjugate therapy enfortumab vedotin.
A new combination of cancer medications has been shown in research to extend overall survival in patients with advanced bladder cancer more than the chemotherapies currently used as the standard ...
Hodgkin lymphoma, germ cell tumours, non-small cell lung cancer, bladder cancer and primary immune thrombocytopenia: Neurotoxicity, myelosuppression, myocardial ischaemia (rare) and myocardial infarction (rare). Vincristine: IV: As above.
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