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The Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, commonly called the Beers List, [1] are guidelines published by the American Geriatrics Society (AGS) for healthcare professionals to help improve the safety of prescribing medications for adults 65 years and older in all except palliative settings.
Biotinidase deficiency is an autosomal recessive metabolic disorder in which biotin is not released from proteins in the diet during digestion or from normal protein turnover in the cell. This situation results in biotin deficiency. Biotin is an important water-soluble nutrient that aids in the metabolism of fats, carbohydrates, and proteins.
Normally, the amount of biotin in the body is regulated by dietary intake, biotin transporters (monocarboxylate transporter 1 and sodium-dependent multivitamin transporter), peptidyl hydrolase biotinidase (BTD), and the protein ligase holocarboxylase synthetase. When any of these regulatory factors are inhibited, biotin deficiency could occur. [23]
Experts agree that eating wholesome, healthy meals, reducing calories, and increasing physical activity are the best ways to lose weight and keep it off long-term. Still, many people turn to ...
The science behind weight management is complex, but one of the key concepts that governs weight management is Energy Balance. [9] Energy Balance is the phrase used to describe the difference between the number of calories a person consumes and the number of calories that same person expends (a.k.a. burns) in a given time period. [9]
A separate study showed that fish-oil derived omega-3s may improve muscle mass, strength, and physical function in older adults with stable weight, and HMB improved both muscle mass and strength ...
In older adults, malnutrition is typically indicated by unintentional weight loss or a low body mass index, though hidden deficiencies, such as those involving micronutrients, are often harder to detect and frequently go unnoticed, especially in community-dwelling seniors.
The US National Academy of Medicine estimates upper limits for vitamins and minerals when evidence for a true limit is sufficient. For biotin, however, there is no upper limit because the adverse effects of high biotin intake have not been determined. [2] The EFSA also reviewed safety and reached the same conclusion as in the United States. [11]