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The mitotic index is a measure of cellular proliferation. [1] It is defined as the percentage of cells undergoing mitosis in a given population of cells. Mitosis is the division of somatic cells into two daughter cells. Durations of the cell cycle and mitosis vary in different cell types. An elevated mitotic index indicates more cells are dividing.
The models can be simulated and analysed using Python libraries, but PySB models can also be exported into BNGL, [4] kappa, [1] and SBML. [34] Models involving multi-state and multi-component species can also be specified in Level 3 of the Systems Biology Markup Language (SBML) [34] using the multi package. A draft specification is available.
Cells in the mitotic phase are identified by the typical appearance of their chromosomes in the cell during the mitotic phase of the cell cycle. [4] Usually the number of mitotic figures is expressed as the total number in a defined number of high power fields, such as 10 mitoses in 10 high power fields.
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase , methylating lysine -9 of histone H3 .
Christopher L. Frank1 and Li-Huei Tsai1, 2 (2009). Alternative functions of core cell cycle regulators in neuronal migration, neuronal maturation, and synaptic plasticity. NIH Public Access 62, 312–326. Fisher, R.P. (2012). The CDK network: Linking cycles of cell sdivision and gene expression. Genes and Cancer 3, 731–738. Frade, J.M. (2000).
where is the gamma function, is the modified Bessel function of the second kind, and ρ and are positive parameters of the covariance. A Gaussian process with Matérn covariance is ⌈ ν ⌉ − 1 {\displaystyle \lceil \nu \rceil -1} times differentiable in the mean-square sense.
Mad2 (mitotic arrest deficient 2) is an essential spindle checkpoint protein. The spindle checkpoint system is a regulatory system that restrains progression through the metaphase -to- anaphase transition.
Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk complex rise through the cell cycle [2] until mitosis, where they fall abruptly due to degradation of cyclin B (Cdk1 is constitutively present). [3]