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Nortriptyline is an active metabolite of amitriptyline by demethylation in the liver. Chemically, it is a secondary amine dibenzocycloheptene and pharmacologically it is classed as a first-generation antidepressant. [36] Nortriptyline may also have a sleep-improving effect due to antagonism of the H 1 and 5-HT 2A receptors. [37]
Nortriptyline reaches 10% higher level in the blood plasma than the parent drug amitriptyline and 40% greater area under the curve, and its action is an important part of the overall action of amitriptyline. [5] [9] Another active metabolite is (E)-10-hydroxynortriptyline, which is a norepinephrine uptake inhibitor four times weaker than ...
Nortriptyline. Protriptyline. Trimipramine. Viorel Kurnosov/istockphoto. Amitriptyline. Amitriptyline, sold under the name Elavil, is a tricyclic antidepressant used to treat depression ...
The compounds described share a tricyclic backbone different from the backbone of the TCA amitriptyline. Merck introduced the second member of the TCA family, amitriptyline (Elavil), in 1961. [60] This compound has a different three-ring structure than imipramine.
This is a list of psychiatric medications used by psychiatrists and other physicians to treat mental illness or distress.. The list is ordered alphabetically according to the condition or conditions, then by the generic name of each medication.
[22] [23] Protriptyline is a secondary amine TCA, with its N-methylated analog N–methylprotriptyline being a tertiary amine, and a structural isomer of amitriptyline. [24] [25] The tertiary amine analog of protriptyline, N–methylprotriptyline, has not been marketed. Other secondary amine TCAs include desipramine and nortriptyline.
Originally, the manufacturer claimed that maprotiline is better tolerated than other TCAs and TeCAs. However, seizures, leukopenia and skin reactions occur more often with maprotiline than with comparable drugs (e.g., amitriptyline, protriptyline, mirtazapine).
Amitriptylinoxide (brand names Amioxid, Ambivalon, Equilibrin), or amitriptyline N-oxide, is a tricyclic antidepressant (TCA) which was introduced in Europe in the 1970s for the treatment of depression. [1] Amitriptylinoxide is both an analogue and metabolite of amitriptyline, and has similar effects as well as equivalent efficacy as an ...
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