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Levothyroxine, also known as L-thyroxine, is a synthetic form of the thyroid hormone thyroxine (T 4). [5] [8] It is used to treat thyroid hormone deficiency (hypothyroidism), including a severe form known as myxedema coma. [5]
Levothyroxine is a frequently prescribed drug in the United States, particularly for older people, as lower thyroid function can be associated with aging. Questions remain over how appropriately ...
For patients taking levothyroxine, TSH may be boosted by discontinuing levothyroxine for 3–6 weeks. [5] This long period of hormone withdrawal is required because of levothyroxine's relatively long biological half-life, and may result in symptoms of hypothyroidism in the patient. The shorter half-life of liothyronine permits a withdrawal ...
Desiccated Thyroid became a commercial treatment option in 1934 with Westhroid, [citation needed]. In the early 1960s, desiccated thyroid hormones (thyroid extract) began to be replaced by levothyroxine (synthetic T4), or by combinations of T4 and T3. Replacement occurred faster in the United Kingdom than in North America, but by the 1980s more ...
The thyroid system of the thyroid hormones T 3 and T 4 [1] Thyroid hormones are any hormones produced and released by the thyroid gland, namely triiodothyronine (T 3) and thyroxine (T 4). They are tyrosine-based hormones that are primarily responsible for regulation of metabolism. T 3 and T 4 are partially composed of iodine, derived from food. [2]
Thyroid diseases are highly prevalent worldwide, [10] [11] [12] and treatment varies based on the disorder. Levothyroxine is the mainstay of treatment for people with hypothyroidism, [13] while people with hyperthyroidism caused by Graves' disease can be managed with iodine therapy, antithyroid medication, or surgical removal of the thyroid ...
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They inhibit release of thyroid hormones by the thyroid gland.The most studied drug in this class is lithium, which inhibits thyroid hormone secretion by inhibiting iodotyrosine coupling, thyroidal iodide uptake, and alteration in structure of thyroglobulin, [10] a protein which acts as a substrate for the synthesis of thyroid hormones and storage of inactive forms of T3, T4 and iodine within ...