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  2. Mevalonate kinase deficiency - Wikipedia

    en.wikipedia.org/wiki/Mevalonate_kinase_deficiency

    Mevalonate kinase (MVK) is an enzyme involved in biosynthesis isoprenoids and is necessary for the conversion of mevalonate to mevalonate-5-phosphate in the presence of Mg 2+. Downstream of this enzyme, mevalonate-5-phosphate is converted into non-sterol (geranylgeranyl, farnesyl) or sterol isoprenoids (cholesterol). MKD is due to a pathogenic ...

  3. Mevalonate kinase - Wikipedia

    en.wikipedia.org/wiki/Mevalonate_kinase

    Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. [6] As the second enzyme in the Mevalonate pathway, it catalyzes the phosphorylation of Mevalonic acid to produce Mevalonate-5-phosphate. [ 8 ]

  4. Mevalonate pathway - Wikipedia

    en.wikipedia.org/wiki/Mevalonate_pathway

    mevalonate-3-phosphate-5-kinase: Mevalonate-3-phosphate is phosphorylated at the 5-OH position to yield mevalonate-5-phosphate (also called phosphomevalonic acid). 1 ATP is consumed. phosphomevalonate kinase: mevalonate-5-phosphate is phosphorylated to yield mevalonate-5-pyrophosphate. 1 ATP is consumed. mevalonate-5-pyrophosphate decarboxylase

  5. More Than Half of People with Diabetes Are Deficient in This ...

    www.aol.com/more-half-people-diabetes-deficient...

    More than 38 million Americans have diabetes, and between 90% and 95% of them have type 2 diabetes. While most are adults over the age of 45, an increasing number of children and teens are also ...

  6. Some Federal Health Agencies Resume Public Communications ...

    www.aol.com/lifestyle/health-agency-reports-cdc...

    Some federal health websites and reports have reappeared after the Trump administration ordered a pause on public communications from agencies like the CDC, FDA, and NIH in January.

  7. 5 ‘Bad’ Fats You Should Be Eating for Better Heart Health ...

    www.aol.com/5-bad-fats-eating-better-125100107.html

    For people with healthy cholesterol levels, eating a moderate amount of dairy products (up to 200 grams per day), whether low or full-fat, may not negatively affect their heart disease risk.

  8. HMG-CoA reductase - Wikipedia

    en.wikipedia.org/wiki/HMG-CoA_reductase

    An excellent review on regulation of the mevalonate pathway by Nobel Laureates Joseph Goldstein and Michael Brown adds specifics: HMG-CoA reductase is phosphorylated and inactivated by an AMP-activated protein kinase, which also phosphorylates and inactivates acetyl-CoA carboxylase, the rate-limiting enzyme of fatty acid biosynthesis. [37]

  9. List of primary immunodeficiencies - Wikipedia

    en.wikipedia.org/wiki/List_of_primary_immuno...

    Hyper-IgD syndrome (Mevalonate kinase deficiency) CIAS1-related diseases: Muckle–Wells syndrome; Familial cold autoinflammatory syndrome, types 1, 2, 3, and 4; Neonatal onset multisystem inflammatory disease; NLRP1 deficiency; PAPA syndrome (pyogenic sterile arthritis, pyoderma gangrenosum, acne) ADAM17 deficiency; Blau syndrome