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  2. What Is Low Testosterone & What Causes It? - AOL

    www.aol.com/low-testosterone-causes-125700734.html

    Some experts argue that 300 ng/dL is not an accurate cut-off for normal testosterone levels because the guideline was based ... occur when one or both testicles fail to fully migrate into the ...

  3. Testosterone - Wikipedia

    en.wikipedia.org/wiki/Testosterone

    Testosterone is the primary male sex hormone and androgen in males. [3] In humans, testosterone plays a key role in the development of male reproductive tissues such as testicles and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair.

  4. Hypogonadism - Wikipedia

    en.wikipedia.org/wiki/Hypogonadism

    The free androgen index, essentially a calculation based on total testosterone and sex hormone-binding globulin levels, is the worst predictor of free testosterone levels and should not be used. [17] Measurement by equilibrium dialysis or mass spectroscopy is generally required for accurate results, particularly for free testosterone which is ...

  5. Sexual differentiation in humans - Wikipedia

    en.wikipedia.org/wiki/Sexual_differentiation_in...

    Subsequent development of one set and degeneration of the other depends on the presence or absence of two testicular hormones: testosterone and anti-Müllerian hormone (AMH). Disruption of typical development may result in the development of both, or neither, duct system, which may produce morphologically intersex individuals.

  6. Androgen insensitivity syndrome - Wikipedia

    en.wikipedia.org/wiki/Androgen_insensitivity...

    In the presence of testosterone and functional androgen receptors, the Wolffian ducts develop into the epididymides, vasa deferentia, and seminal vesicles. [67] If the testes fail to secrete testosterone, or the androgen receptors do not function properly, the Wolffian ducts degenerate. [69]

  7. Leydig cell - Wikipedia

    en.wikipedia.org/wiki/Leydig_cell

    Leydig cells release a class of hormones called androgens (19-carbon steroids). [8] They secrete testosterone, androstenedione and dehydroepiandrosterone (DHEA), when stimulated by the luteinizing hormone (LH), which is released from the anterior pituitary in response to gonadotropin releasing hormone which in turn is released by the hypothalamus.

  8. Androgen backdoor pathway - Wikipedia

    en.wikipedia.org/wiki/Androgen_backdoor_pathway

    The androgen backdoor pathways occur without the involvement of testosterone (T) and/or androstenedione (A4), which are part of the conventional, canonical (classic) [30] [31] [11] androgenic pathway. [15] In the canonical pathways of androgen biosynthesis, DHT is synthesized from T via 5α-reduction, so that 5α-reduction of T, a C

  9. Male reproductive system - Wikipedia

    en.wikipedia.org/wiki/Male_reproductive_system

    The major androgens secreted by these cells is testosterone and secretion begins 8 to 10 weeks after conception. Testosterone secretion reaches a peak at 12 to 14 weeks, and declines to very low levels by the end of the second trimester (about 21 weeks). Levels are the barely detectable 4–6 months of age postnatal.

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