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Citalopram was approved for medical use in the United States in 1998. [7] It is on the World Health Organization's List of Essential Medicines. [11] It is available as a generic medication. [12] In 2022, it was the 40th most commonly prescribed medication in the United States, with more than 15 million prescriptions. [13] [14]
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification.
SERT occupancy by SRIs at clinically approved dosages Medication Dosage range (mg/day) [4] ~80% SERT occupancy (mg/day) [5] [6] Ratio (dosage / 80% occupancy) Citalopram: 20–40: 40: 0.5–1 Escitalopram: 10–20: 10: 1–2 Fluoxetine: 20–80: 20: 1–4 Fluvoxamine: 50–350: 70: 0.71–5 Paroxetine: 10–60: 20: 0.5–3 Sertraline: 25–200: ...
Paroxetine was the first drug to be approved for social anxiety disorder and it is considered effective for this disorder; sertraline and fluvoxamine were later approved for it as well. Escitalopram and citalopram are used off-label with acceptable efficacy, while fluoxetine is not considered to be effective for this disorder. [22]
Among adults 60 or older, nearly 30% reported taking aspirin to prevent cardiovascular disease, and around 5% of all adults 60 or older reported using aspirin without medical advice.
Saphris – atypical antipsychotic used to treat schizophrenia and bipolar disorder; Serax – anti-anxiety medication of the benzodiazepine class, often used to help during detoxification from alcohol or other addictive substances; Serentil (mesoridazine) – an antipsychotic drug used in the treatment of schizophrenia [1]
Sertraline and fluvoxamine extended-release were later approved for it as well, while escitalopram is used off-label with acceptable efficiency. However, there is not enough evidence to support Citalopram for treating social anxiety disorder, and fluoxetine was no better than a placebo in clinical trials.
In December 2011, the UK implemented new restrictions on the maximum daily doses at 20 mg for adults and 10 mg for those older than 65 years or with liver impairment. [41] [42] The US Food and Drug Administration and Health Canada did not similarly order restrictions on escitalopram dosage, only on its predecessor citalopram. [43]