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The entire pathway begins and ends in the cerebral cortex, and its entire course is the following: [2] (Motor and sensory areas of) cerebral cortex → corticopontine fibers → (ipsilateral) nuclei pontis (synapse) → pontocerebellar fibers (decussation within pons) → middle cerebellar peduncle → (contralateral) (cerebellar cortex and (collaterals) dentate nucleus of) posterior lobe of ...
Pontocerebellar fibers are the sole efferent pathway of the pontine nuclei. The fibers mostly decussate within the pons to pass through the (contralateral) middle cerebellar peduncle to terminate in the contralateral cerebellum as mossy fibers; they form terminal synapses in the cerebellar cortex, but also issue collaterals to the cerebellar nuclei.
The middle cerebellar peduncle is the largest of the three cerebellar peduncles. It connects the pons and cerebellum.It consists almost entirely of fibers passing from the pons to the cerebellum (fibrocerebellar fibers); the fibers arise from the pontine nuclei and decussate within the pons before entering the peduncle [1] to end in the contralateral cerebellar hemisphere.
Mesocortical pathway; Mesolimbic pathway; Nigrostriatal pathway; Tuberoinfundibular pathway; Serotonergic pathways. Raphe Nuclei; Norepinephrine Pathways Locus coeruleus and other noradrenergic cell groups; Epinephrine pathways from adrenergic cell groups; Glutamate and acetylcholine pathways from mesopontine nuclei
The human cerebellum is located at the base of the brain, with the large mass of the cerebrum above it, and the portion of the brainstem called the pons in front of it. It is separated from the overlying cerebrum by a layer of tough dura mater called the cerebellar tentorium; all of its connections with other parts of the brain travel through the pons.
[9] [10] It reaches the cerebellum partly through the brachium conjunctivum (superior cerebellar peduncle) and partly through the restiform body (inferior cerebellar peduncle). [ 10 ] Pathway for dorsal and spinocuneocerebellar tracts
All the fibers from the corticopontine system terminate in the pontine nuclei.The fibers descend through the sublenticular and retrolenticular of internal capsule, then traverse the midbrain through the basis pedunculi (i.e. ventral part of cerebral peduncle) to reach the pontine nuclei and synapse with neurons that give rise to pontocerebellar fibers.
Ascending fibers are second-order axons projecting from the gustatory nucleus (the rostral part of the solitary nucleus] to the ventral posteromedial nucleus of thalamus [1] [3] (third-order neurons in turn project to the gustatory cortex).