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IARC group 1 Carcinogens are substances, chemical mixtures, and exposure circumstances which have been classified as carcinogenic to humans by the International Agency for Research on Cancer (IARC). [1] This category is used when there is sufficient evidence of carcinogenicity in humans.
The IARC Monographs on which this list is based assess the hazard linked to the agents, they do not assess the cancer risk of the agents. [1] The list is up-to-date as of January 2024. [ 2 ]
Ted S. Gansler, the director of medical content for the American Cancer Society, stated "There is no convincing evidence that antiperspirant or deodorant use increases cancer risk". [6] However, there is continued concern over the use of aluminium chlorohydrate in cosmetics as the risk of toxic build up over time has not been ruled out. [8]
Aluminium chloride, also known as aluminium trichloride, is an inorganic compound with the formula AlCl 3. It forms a hexahydrate with the formula [Al(H 2 O) 6 ]Cl 3 , containing six water molecules of hydration .
Cancer slope factors (CSF) are used to estimate the risk of cancer associated with exposure to a carcinogenic or potentially carcinogenic substance. A slope factor is an upper bound, approximating a 95% confidence limit , on the increased cancer risk from a lifetime exposure to an agent by ingestion or inhalation .
The following is a list of chemicals published as a requirement of Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductive toxicity" as of January 3, 2020. [1]
The two graphics illustrate sampling distributions of polygenic scores and the predictive ability of stratified sampling on polygenic risk score with increasing age. + The left panel shows how risk—(the standardized PRS on the x-axis)—can separate 'cases' (i.e., individuals with a certain disease, (red)) from the 'controls' (individuals without the disease, (blue)).
It assigns scores to individuals based on risk factors; a higher score reflects higher risk. The score reflects the level of risk in the presence of some risk factors (e.g. risk of mortality or disease in the presence of symptoms or genetic profile, risk financial loss considering credit and financial history, etc.).