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This list of manually curated human transcription factors is taken from Lambert, Jolma, Campitelli et al. [1] It was assembled by manual curation. More detailed information is found in the manuscript and the web site accompanying the paper (Human Transcription Factors)
Other transcription factors differentially regulate the expression of various genes by binding to enhancer regions of DNA adjacent to regulated genes. These transcription factors are critical to making sure that genes are expressed in the right cell at the right time and in the right amount, depending on the changing requirements of the organism.
[2] A transcription factor is a protein that binds to specific DNA sequences (enhancer or promoter), either alone or with other proteins in a complex, to control the rate of transcription of genetic information from DNA to messenger RNA by promoting (serving as an activator) or blocking (serving as a repressor) the recruitment of RNA polymerase.
Several cell function specific transcription factor proteins (in 2018 Lambert et al. indicated there were about 1,600 transcription factors in a human cell [41]) generally bind to specific motifs on an enhancer [22] and a small combination of these enhancer-bound transcription factors, when brought close to a promoter by a DNA loop, govern the ...
229906 Ensembl ENSG00000137947 ENSMUSG00000028271 UniProt Q00403 P62915 RefSeq (mRNA) NM_001514 NM_145546 RefSeq (protein) NP_001505 NP_663521 Location (UCSC) Chr 1: 88.85 – 88.89 Mb Chr 3: 142.47 – 142.49 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II ...
Transcription factors (TFs) are proteins that bind DNA and thus regulate the trasncription process. The binding is sequence-specific. A sequence motif [5] is a model that describes the common pattern of the DNA binding sites [6] that a particular TF prefers to bind. One of the possible representations of the model is the Position-Weight Matrix ...
The positive transcription elongation factor, P-TEFb, is a multiprotein complex that plays an essential role in the regulation of transcription by RNA polymerase II (Pol II) in eukaryotes. [1] Immediately following initiation Pol II becomes trapped in promoter proximal paused positions on the majority of human genes (Figure 1).
[1] [2] [3] TF II F is encoded by the GTF2F1, GTF2F2, and GTF2F2L genes. [4] [5] [6] TF II F binds to RNA polymerase II when the enzyme is already unbound to any other transcription factor, thus preventing it from contacting DNA outside the promoter. Furthermore, TF II F stabilizes the RNA polymerase II while it's contacting TBP and TF II B.