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Isopeptide bond between lysine and aspartate/asparagine. An isopeptide bond is a type of amide bond formed between a carboxyl group of one amino acid and an amino group of another. An isopeptide bond is the linkage between the side chain amino or carboxyl group of one amino acid to the α-carboxyl, α-amino group, or the side chain of another ...
Isopeptide bonds occur in the linkage of protein amino acid side chains to proteins such as ubiquitin and SUMO in the protein degradation pathway. In eukaryotes, enzymes with isopeptidase activity are often involved in this pathway; all five classes of deubiquitinating enzymes have isopeptidase activity. [1]
[4] [5] The amide group is called a peptide bond when it is part of the main chain of a protein, and an isopeptide bond when it occurs in a side chain, as in asparagine and glutamine. It can be viewed as a derivative of a carboxylic acid ( R−C(=O)−OH ) with the hydroxyl group ( −OH ) replaced by an amino group ( −NR′R″ ); or ...
Peptide bond formation via dehydration reaction. When two amino acids form a dipeptide through a peptide bond, [1] it is a type of condensation reaction. [2] In this kind of condensation, two amino acids approach each other, with the non-side chain (C1) carboxylic acid moiety of one coming near the non-side chain (N2) amino moiety of the other.
Bonds formed by transglutaminase exhibit high resistance to proteolytic degradation (proteolysis). [2] The reaction is [1] Gln-(C=O)NH 2 + NH 2-Lys → Gln-(C=O)NH-Lys + NH 3. Transglutaminases can also join a primary amine ( RNH 2 ) to the side chain carboxyamide group of a protein/peptide bound glutamine residue thus forming an isopeptide ...
Move over, Wordle, Connections and Mini Crossword—there's a new NYT word game in town! The New York Times' recent game, "Strands," is becoming more and more popular as another daily activity ...
Becoming a host city for the Super Bowl is a long and difficult process, one that starts years before the game actually takes place. When all is said and done, the decision behind the host city ...
U.S. Arab American and Muslim leaders, including some who supported Donald Trump in the 2024 election, criticized the president's proposal for the U.S. to take over Gaza and resettle Palestinians ...