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In microbiology, the minimum inhibitory concentration (MIC) is the lowest concentration of a chemical, usually a drug, which prevents visible in vitro growth of bacteria or fungi. [ 1 ] [ 2 ] MIC testing is performed in both diagnostic [ 1 ] [ 2 ] and drug discovery laboratories.
Breakpoints for the same organism and antibiotic may differ based on the site of infection: [29] for example, the CLSI generally defines Streptococcus pneumoniae as sensitive to intravenous penicillin if MICs are ≤0.06 μg/ml, intermediate if MICs are 0.12 to 1 μg/ml, and resistant if MICs are ≥2 μg/ml, but for cases of meningitis, the ...
Agar dilution is one of two methods (along with broth dilution) used by researchers to determine the minimum inhibitory concentration (MIC) of antibiotics. It is the dilution method most frequently used to test the effectiveness of new antibiotics when a few antibiotics are tested against a large panel of different bacteria.
A unit of time is any particular time interval, used as a standard way of measuring or expressing duration. The base unit of time in the International System of Units (SI), and by extension most of the Western world , is the second , defined as about 9 billion oscillations of the caesium atom.
Following the allotted time, the plate is removed and checked for bacterial growth. If the broth became cloudy or a layer of cells formed at the bottom, then bacterial growth has occurred. The results of the broth microdilution method are reported in Minimum Inhibitory Concentration (MIC), or the lowest concentration of antibiotics that stopped ...
Without hardware support (and in multitasking environments), debuggers have to implement breakpoints in software. For instruction breakpoints, this is a comparatively simple task of replacing the instruction at the location of the breakpoint by either: an instruction that calls the debugger directly (e.g. a system call, or int3 in case of x86) or
The MIC is determined from the zero intercept of a linear regression fit through the data. [12] The intercept itself is the logarithm of the MIC. The slope of the regression line is related to the diffusion coefficient of that particular antibiotic in the agar.
The study aimed to define an all-cause hospital mortality breakpoint for carbapenem MICs that were adjusted for risk factors. Another objective was to determine if a similar breakpoint existed for indirect outcomes, such as the time to death and length of stay after infection for survivors.