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  2. Paclitaxel total synthesis - Wikipedia

    en.wikipedia.org/wiki/Paclitaxel_total_synthesis

    Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). [1] This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew ( Taxus brevifolia ).

  3. Nicolaou Taxol total synthesis - Wikipedia

    en.wikipedia.org/wiki/Nicolaou_Taxol_total_synthesis

    The Nicolaou Taxol total synthesis, published by K. C. Nicolaou and his group in 1994 concerns the total synthesis of taxol. [1] Taxol is an important drug in the treatment of cancer but also expensive because the compound is harvested from a scarce resource, namely the pacific yew .

  4. Holton Taxol total synthesis - Wikipedia

    en.wikipedia.org/wiki/Holton_Taxol_total_synthesis

    The Holton Taxol total synthesis, published by Robert A. Holton and his group at Florida State University in 1994, was the first total synthesis of Taxol (generic name: paclitaxel). [1] [2] The Holton Taxol total synthesis is a good example of a linear synthesis. The synthesis starts from patchoulene oxide, a commercially available natural ...

  5. Danishefsky Taxol total synthesis - Wikipedia

    en.wikipedia.org/wiki/Danishefsky_Taxol_total...

    Danishefsky Taxol total synthesis overview from raw material perspective. The Danishefsky Taxol total synthesis in organic chemistry is an important third Taxol synthesis published by the group of Samuel Danishefsky in 1996 [1] two years after the first two efforts described in the Holton Taxol total synthesis and the Nicolaou Taxol total synthesis.

  6. Mukaiyama Taxol total synthesis - Wikipedia

    en.wikipedia.org/.../Mukaiyama_Taxol_total_synthesis

    The Mukaiyama taxol total synthesis published by the group of Teruaki Mukaiyama of the Tokyo University of Science between 1997 and 1999 was the 6th successful taxol total synthesis. The total synthesis of Taxol is considered a hallmark in organic synthesis. This version is a linear synthesis with ring formation taking place in the order C, B ...

  7. Samuel J. Danishefsky - Wikipedia

    en.wikipedia.org/wiki/Samuel_J._Danishefsky

    The Danishefsky Taxol total synthesis was the third synthesis of taxol, a highly topical natural product. [4] Together with the Holton Taxol total synthesis and the Nicolaou Taxol total synthesis, these multistep sequences illustrate the state of the art in total synthesis.

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  9. Paclitaxel - Wikipedia

    en.wikipedia.org/wiki/Paclitaxel

    The biosynthesis of Taxol is illustrated in more detail in the figure, with steps 1-7 all occurring in the enzyme taxadiene synthase (TS on the figure). Taxol's biosynthesis begins with E,E,E-GGPP losing pyrophosphate via an SN1 mechanism (step 1 in the figure). The double-bond attacks the cation via electrophilic addition, yielding a tertiary ...