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The complement fixation test is an immunological medical test that can be used to detect the presence of either specific antibody or specific antigen in a patient's serum, based on whether complement fixation occurs. It was widely used to diagnose infections, particularly with microbes that are not easily detected by culture methods, and in ...
The Wassermann test or Wassermann reaction (WR) [1] is an antibody test for syphilis, named after the bacteriologist August Paul von Wassermann, based on complement fixation. It was the first blood test for syphilis and the first in the nontreponemal test (NTT) category. Newer NTTs, such as the RPR and VDRL tests, have mostly replaced it ...
Diagnostic tools to measure complement activity include the total complement activity test. [52] The presence or absence of complement fixation upon a challenge can indicate whether particular antigens or antibodies are present in the blood. This is the principle of the complement fixation test. [citation needed]
A variety of tests can be used to measure TCA, but the most commonly used on is the CH50 test. [ 1 ] [ 2 ] Other tests include the liposome immunoassay (LIA), [ 3 ] single tube titration method, [ 4 ] and the plate-hemolysis method.
Direct immunofluorescence can be used to detect deposits of immunoglobulins and complement proteins in biopsies of skin, kidney and other organs. Their presence is indicative of an autoimmune disease. When skin not exposed to the sun is tested, a positive direct IF (the so-called Lupus band test) is an evidence of systemic lupus erythematosus. [2]
The references used may be made clearer with a different or consistent ... Complement fixation assay. The complement fixation test was modified to assay Antiserum ...
The so-called "Wassermann test" allowed for early detection of the disease (despite its nonspecific symptoms), and thus prevention of transmission. He attributed the development of the test to earlier findings of Jules Bordet and Octave Gengou (complement fixation reaction) and to a hypothesis introduced by Paul Ehrlich in his interpretation of ...
The direct Coombs test is used to detect antibodies or complement proteins attached to the surface of red blood cells. To perform the test, a blood sample is taken and the red blood cells are washed (removing the patient's plasma and unbound antibodies from the red blood cells) and then incubated with anti-human globulin ("Coombs reagent").