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  2. Lifestyle causes of type 2 diabetes - Wikipedia

    en.wikipedia.org/wiki/Lifestyle_causes_of_type_2...

    Obesity has been found to contribute to approximately 55% of cases of type 2 diabetes; [10] chronic obesity leads to increased insulin resistance that can develop into type 2 diabetes, [11] most likely because adipose tissue (especially that in the abdomen around internal organs) is a source of several chemical signals, hormones and cytokines, to other tissues.

  3. Type 2 diabetes - Wikipedia

    en.wikipedia.org/wiki/Type_2_diabetes

    Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [6] Common symptoms include increased thirst , frequent urination , fatigue and unexplained weight loss . [ 3 ]

  4. Genetic causes of type 2 diabetes - Wikipedia

    en.wikipedia.org/wiki/Genetic_causes_of_type_2...

    While obesity is an independent risk factor for type 2 diabetes that may be linked to lifestyle, obesity is also a trait that may be strongly inherited. [21] [22] Other research also shows that type 2 diabetes can cause obesity as an effect of the changes in metabolism and other deranged cell behavior attendant on insulin resistance. [23]

  5. Epidemiology of diabetes - Wikipedia

    en.wikipedia.org/wiki/Epidemiology_of_diabetes

    Diabetes was the 9th-leading cause of mortality globally in 2020, attributing to over 2 million deaths annually due to diabetes directly, and to kidney disease due to diabetes. [2] The primary causes of type 2 diabetes is diet and physical activity, which can contribute to increased BMI, poor nutrition, hypertension, alcohol use and smoking ...

  6. Thrifty gene hypothesis - Wikipedia

    en.wikipedia.org/wiki/Thrifty_gene_hypothesis

    Many attempts have been made to search for one or more genes contributing to thrift. Modern tools of genome wide association studies have revealed many genes with small effects associated with obesity or type 2 diabetes but all of them together explain only between 1.4 and 10% of population variance.

  7. Disposition index - Wikipedia

    en.wikipedia.org/wiki/Disposition_index

    Thus a lowering of disposition index predicts the conversion of insulin resistance to diabetes mellitus type 2. [13] Disposition index, but not insulin resistance, can predict type 2 diabetes in persons with normal blood glucose levels, but who do not have a family history (genetic predisposition) to type 2 diabetes. [14] Disposition index can ...

  8. Health equity - Wikipedia

    en.wikipedia.org/wiki/Health_equity

    Changing the distribution of health services. Health services play a major role in health equity. Health inequities stem from lack of access to care due to poor economic status and an interaction among other social determinants of health. The majority of high quality health services are distributed among the wealthy people in society, leaving ...

  9. Biomarkers of diabetes - Wikipedia

    en.wikipedia.org/wiki/Biomarkers_of_diabetes

    Type 2 diabetes is a progressive condition in which the body becomes resistant to the normal effects of insulin and/or gradually loses the capacity to produce enough insulin in the pancreas. [2] Pre-diabetes means that the blood sugar level is higher than normal but not yet high enough to be type 2 diabetes. [3]

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