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Diabetes currently affects more than 74 million Indians, which is more than 8.3% of the adult population. [1] It is estimated to be around 57% of the current cases of diabetes to be undiagnosed. [17] Among young and middle aged adults the prevalence of diabetes is 6.7% and prediabetes is 5.6% according to the National Family Health Survey-4. [18]
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Type 2 diabetes accounts for 90%-95% of all cases. [1] In 2017, approximately 24.7 million people were diagnosed with diabetes in the United States, approximately 7.6% of the total population (and 9th in the world). [2] Diabetes is the leading cause of kidney failure, non-traumatic lower-limb amputations, and blindness in adults.
However, environmental factors (almost certainly diet and weight) play a large part in the development of type 2 diabetes in addition to any genetic component. Genetic risk for type 2 diabetes changes as humans first began migrating around the world, implying a strong environmental component has affected the genetic-basis of type 2 diabetes.
In 2012, diabetes caused 356,586 deaths in this region, a zone with the highest prevalence of diabetes in adults (11%) in the world. [ 16 ] Turkey reported a prevalence of 33.9% for metabolic syndrome (MS), with a higher prevalence in women (39.6%) than in men (28%). [ 17 ]
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Obesity has been found to contribute to approximately 55% of cases of type 2 diabetes; [10] chronic obesity leads to increased insulin resistance that can develop into type 2 diabetes, [11] most likely because adipose tissue (especially that in the abdomen around internal organs) is a source of several chemical signals, hormones and cytokines, to other tissues.
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