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Benzatropine , [2] known as benztropine in the United States and Japan, [3] is a medication used to treat movement disorders like parkinsonism and dystonia, as well as extrapyramidal side effects of antipsychotics, including akathisia. [4] It is not useful for tardive dyskinesia. [4] It is taken by mouth or by injection into a vein or muscle. [4]
Medications are used to reverse the symptoms of extrapyramidal side effects caused by antipsychotics or other drugs, by either directly or indirectly increasing dopaminergic neurotransmission. The treatment varies by the type of the EPS, but may involve anticholinergic agents such as procyclidine, benztropine, diphenhydramine, and trihexyphenidyl.
The dose should be reviewed and reduced if side effects occur, though in the short-term an anticholinergic medication benztropine may be helpful for tremor and stiffness, while diazepam may be helpful for akathisia. 100 mg of zuclopenthixol decanoate is roughly equivalent to 20 mg of flupentixol decanoate or 12.5 mg of fluphenazine decanoate.
In pediatrics, it has been used for children with dystonia due to cerebral palsy, [8] [9] [10] and to control drooling. [ 11 ] In organophosphate poisoning , trihexyphenidyl is a more effective antidote than atropine to counteract the cholinergic crisis, seizures, and neuropathology.
Oculogyric crisis (OGC) is a rare sudden, paroxysmal, dystonic reaction that may manifest in response to specific drugs, particularly neuroleptics, or medical conditions, such as movement disorders.
Lilly said patients could purchase higher-dose 7.5 milligram and 10mg vials of Zepbound for $499 a month on the LillyDirect website. That is nearly 23% less than the $650 Lilly charges for auto ...
Dose-dependent side effects are frequent. Particularly geriatric patients may react with confusional states or develop delirium. CNS : Drowsiness, vertigo, headache, and dizziness are frequent. With high doses nervousness, agitation, anxiety, delirium, and confusion are noted. Biperiden may be abused due to a short acting mood-elevating and ...
Drooling is often treated with botulinum toxin A, benztropine or anticholinergics (e.g. glycopyrrolate). A review on the treatment of sialorrhea in children with cerebral palsy found that it was not possible to tell whether these interventions worked or were safe. [67] Anticholinergics may contribute to constipation. [68]