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An example of this is the facially cationic peptide C18G, which was designed from the C-terminal domain of human platelet factor IV. [70] Currently, the most widely used antimicrobial peptide is nisin ; being the only FDA approved antimicrobial peptide, it is commonly used as an artificial preservative.
Cathelicidin antimicrobial peptide (CAMP) is an antimicrobial peptide encoded in the human by the CAMP gene. [1] The active form is LL-37 . In humans, CAMP encodes the peptide precursor CAP-18 (18 kDa), which is processed by proteinase 3 -mediated extracellular cleavage into the active form LL-37.
Pages in category "Antimicrobial peptides" The following 54 pages are in this category, out of 54 total. This list may not reflect recent changes. ...
The human genome contains theta-defensin genes, but they have a premature stop codon, hampering their expression. An artificial human theta-defensin, [40] retrocyclin, was created by 'fixing' the pseudogene, and it was shown to be effective against HIV [41] and other viruses, including herpes simplex virus and influenza A. They act primarily by ...
Surfactin is a cyclic lipopeptide, commonly used as an antibiotic for its capacity as a surfactant. [2] It is an amphiphile capable of withstanding hydrophilic and hydrophobic environments.
Dermcidin is a protein with 110 amino acids that in humans is encoded by the DCD gene. [3] [4] The full-length protein produces derived peptides as proteolysis-inducing factor (PIF) and other anti-microbial peptides, [4] secreted by human eccrine sweat glands onto the skin as a part of the innate host defense of the immune system.
Bacitracin is a polypeptide antibiotic derived from a bacterium, Bacillus subtilis, and acts against bacteria through the inhibition of cell wall synthesis. [6] It does this by inhibiting the removal of phosphate from lipid compounds, thus deactivating its function to transport peptidoglycan; the main component of bacterial cell membranes, to the microbial cell wall.
For example, a recent study of Cecropins A and B demonstrated strongly cytotoxic activity against four bladder cancer cell lines, while benign murine and human fibroblasts were not susceptible to Cecropin A or B. [12] Cecropins from many insect species have been shown to be active against a diverse range of human cancer cell lines. For example ...