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The hallmark symptom of Sjögren syndrome is dry mouth and keratoconjunctivitis sicca (dry eyes). [16] Vaginal dryness, dry skin, and dry nose may also occur. [16] Other organs of the body may also be affected, [17] including the kidneys, blood vessels, lungs, liver, pancreas, and brain. [16] [18]
Paraneoplastic syndrome, Guillain-Barré syndrome, diabetes, amyloidosis, Sjogren's syndrome, and Morvan syndrome. Autoimmune autonomic ganglionopathy is a type of immune-mediated autonomic failure that is associated with antibodies against the ganglionic nicotinic acetylcholine receptor present in sympathetic , parasympathetic , and enteric ...
Cevimeline is used in the treatment of xerostomia (dry mouth) [1] [2] and Sjögren's syndrome. [1] It increases the production of saliva. [2] Side effects.
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Dry eye syndrome, also known as keratoconjunctivitis sicca, is the condition of having dry eyes. [2] Symptoms include dryness in the eye, irritation, redness, discharge, blurred vision, and easily fatigued eyes. Symptoms range from mild and occasional to severe and continuous. [3]
Sensory neuronopathy is thought to involve 40% of neuropathies in Sjogren's syndrome and 5% of all cases of Sjogren's overall, it is usually subacute in onset. Other immune mediated causes of sensory neuronopathy include systemic lupus erythematosus, autoimmune hepatitis and celiac disease. [4] Toxin exposure can also lead to sensory ...
Examples autoimmune conditions are Sjogren's syndrome, autoimmune thyroid disease, and uveitis. [14] Patients with dry eyes may have an inability to produce adequate amount or quality of tears leading to a disruption in their tear film. [15] In addition, those who wear contact lenses or have undergone eye surgeries such as LASIK are at ...
In addition, tirabrutinib is in clinical development by Ono Pharmaceutical and Gilead Sciences [3] in the United States, Europe, and Japan for autoimmune disorders, chronic lymphocytic leukemia, B cell lymphoma, Sjogren's syndrome, pemphigus, and rheumatoid arthritis. [1] Tirabrutinib is an irreversible inhibitor of Bruton's tyrosine kinase. [4]