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An expression quantitative trait locus (eQTL) is a type of quantitative trait locus (QTL), a genomic locus (region of DNA) that is associated with phenotypic variation for a specific, quantifiable trait.
A quantitative trait locus (QTL) is a region of DNA which is associated with a particular phenotypic trait, which varies in degree and which can be attributed to polygenic effects, i.e., the product of two or more genes, and their environment. [2]
[56] [57] [58] One of the strongest eQTL effects observed for a GWA-identified risk SNP is the SORT1 locus. [42] Functional follow up studies of this locus using small interfering RNA and gene knock-out mice have shed light on the metabolism of low-density lipoproteins , which have important clinical implications for cardiovascular disease .
The eQTL analysis determines loci associated with a quantitative trait, where expression studies of loci associated with traits such as allergy are performed, with a functional explanation . Through these studies, an overlap between loci associated with allergy was observed and it loci previously implicated in autoimmune diseases.
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In order to perform this analysis, a reference panel for gene expression should be obtained, such as an expression quantitative trait loci (eQTL), which helps to show gene expression regulation. [4] Using the reference panel, a predictive model can be generated to impute the expression variation of genes.
For humans, the Big Five personality traits, also known as the five-factor model (FFM) or the OCEAN model, is the prevailing model for personality traits. When factor analysis (a statistical technique) is applied to personality survey data, some words or questionnaire items used to describe aspects of personality are often applied to the same person.