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The germinal stage refers to the time from fertilization, through the development of the early embryo, up until implantation. The germinal stage is over at about 10 days of gestation. [2] The zygote contains a full complement of genetic material with all the biological characteristics of a single human being, and develops into the embryo.
In humans, blastocyst formation begins about five days after fertilization when a fluid-filled cavity opens up in the morula, the early embryonic stage of a ball of 16 cells. The blastocyst has a diameter of about 0.1–0.2 mm and comprises 100-200 cells following 7-8 rounds of cleavage (cell division without cell growth).
Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. [1] [2] Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells.
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Implantation bleeding occurs between 7 and 14 days after fertilization, [57] and is a small amount of light vaginal bleeding or spotting that can occur in early pregnancy due to the blastocyst penetrating the lining of the uterus during implantation.
Human embryology is the study of this development during the first eight weeks after fertilization. The normal period of gestation (pregnancy) is about nine months or 36 weeks. The germinal stage refers to the time from fertilization through the development of the early embryo until implantation is completed in the uterus.
The term "conception" refers variably to either fertilization or to formation of the conceptus after its implantation in the uterus, and this terminology is controversial. The zygote will develop into a male if the egg is fertilized by a sperm that carries a Y chromosome , or a female if the sperm carries an X chromosome . [ 5 ]
In humans, decidualization occurs after ovulation during the menstrual cycle. After implantation of the embryo, the decidua further develops to mediate the process of placentation. In the event no embryo is implanted, the decidualized endometrial lining is shed or, as is the case with species that follow the estrous cycle, absorbed. [1]