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  2. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    Metformin has acid dissociation constant values (pK a) of 2.8 and 11.5, so it exists very largely as the hydrophilic cationic species at physiological pH values. The metformin pK a values make it a stronger base than most other basic medications with less than 0.01% nonionized in blood.

  3. 6 Benefits of Taking Metformin (Besides Weight Loss) - AOL

    www.aol.com/6-benefits-taking-metformin-besides...

    2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.

  4. When Is the Best Time to Take Metformin? - AOL

    www.aol.com/best-time-metformin-141700387.html

    There’s no best time to take metformin for weight loss or type 2 diabetes (or any other condition). But taking it at the same time each day can help you stay consistent and avoid missing or ...

  5. Pyruvate kinase - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_kinase

    Metformin, or dimethylbiguanide, is the primary treatment used for type 2 diabetes. Metformin has been shown to indirectly affect pyruvate kinase through the inhibition of gluconeogenesis. Specifically, the addition of metformin is linked to a marked decrease in glucose flux and increase in lactate/pyruvate flux from various metabolic pathways.

  6. Pioglitazone/metformin - Wikipedia

    en.wikipedia.org/wiki/Pioglitazone/metformin

    Metformin is a member of the biguanide class, improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose and improves insulin sensitivity by increasing peripheral glucose uptake and utilization.

  7. Rheumatoid arthritis linked to changes in the gut microbiome ...

    www.aol.com/rheumatoid-arthritis-linked-changes...

    Changes in the gut microbiome may be a tell-tale sign of the onset of rheumatoid arthritis. Image credit: Instants/Getty Images. This article originally appeared on Medical News Today

  8. Metabolic acidosis - Wikipedia

    en.wikipedia.org/wiki/Metabolic_acidosis

    Metabolic acidosis can lead to acidemia, which is defined as arterial blood pH that is lower than 7.35. [6] Acidemia and acidosis are not mutually exclusive – pH and hydrogen ion concentrations also depend on the coexistence of other acid-base disorders; therefore, pH levels in people with metabolic acidosis can range from low to high.

  9. Sitagliptin/metformin - Wikipedia

    en.wikipedia.org/wiki/Sitagliptin/metformin

    In the United States, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes. [5] [6]In the European Union, sitagliptin/metformin is indicated as an adjunct to diet and exercise to improve glycemic control in people with type 2 diabetes; in combination with a sulfonylurea as an adjunct to diet and exercise "in people ...

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