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Relaxin is a protein hormone of about 6000 Da, [1] first described in 1926 by Frederick Hisaw. [2] [3]The relaxin family peptide hormones belong to the insulin superfamily and consists of seven peptides of high structural but low sequence similarity; relaxin-1 (RLN1), 2 (RLN2) and 3 (), and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
Before immunological pregnancy tests were developed in the 1960s, women relied on urine-based pregnancy tests using animals, ranging from mice to frogs. [ 1 ] [ 2 ] Advancements in medical technology have enabled women to accurately check their pregnancy status by using 'pee-on-a-stick' pregnancy test kits at home.
The effect of hCG in maintaining pregnancy . In the human ovary, H2 relaxin is produced by the corpus luteum and by Granulosa cells from large antral follicles. [3] Research has shown that the relaxin gene is expressed once the Granulosa cells have reached a certain luteinised status, by which Granulosa cells differentiate into Luteal cells. [3]
As a paracrine hormone, relaxin helps the non-pregnant uterus become ready for pregnancy. [23] Women's endometrium contains relaxin, which is an essential component that helps prepare the body for early pregnancy. [21] The endometrium is transformed into decidua during the early pregnancy maintenance procedure. [21]
All seven relaxin family peptide hormones are synthesized as pre-prohormones, and subsequently cleaved to form two chains stabilized by an intra-α-chain and two disulfide bonds. [5] Members of the human relaxin peptide family share a similar tertiary structure, composed of a β-chain, c-chain, and α-chain at their carboxyl-terminal.
However, Shola, an English Shepherd who was forced to retire as a mountain rescue dog due to the condition, has helped scientists create a new test that could mean the end of PRA.
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