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Type 2 statins Statins that are fully synthetic and have larger groups linked to the HMG-like moiety are often referred to as type 2 statins. One of the main differences between the type 1 and type 2 statins is the replacement of the butyryl group of type 1 statins by the fluorophenyl group of type 2 statins.
After five years, the study concluded the patients saw a 35% reduction in their cholesterol, and their chances of dying of a heart attack were reduced by 42%. [ 12 ] [ 192 ] In 1995, Zocor and Mevacor both made Merck over US$1 billion .
In 1994, the findings of a Merck-funded study were published in The Lancet concluding the efficacy of statins in lowering cholesterol proving for the first time not only that a "statin reduced 'bad' LDL cholesterol but also that it led to a sharp drop in fatal heart attacks among people with heart disease." [112] [116]
The first statin drug available to the general public was lovastatin. Mevastatin has since been derivatized to the compound pravastatin , which is a pharmaceutical used in the lowering of cholesterol and preventing cardiovascular disease .
There are prescription medications like Niaspan and its generic equivalent niacin ER that deliver 500 to 1,000 milligrams of extended-release niacin that are used to treat high blood cholesterol ...
Red yeast rice [12] is the natural source from which statins were discovered, but the FDA currently disallows any RYR with significant amounts of statin to be sold as a dietary supplement [13] Boswellia serrata [14] L-arginine may enhance the effects of a Statin, but will not lead to a reduction in cholesterol alone. [15] Flaxseed oil [16]
The researchers looked at data on cholesterol levels and dispensed medication from the Swedish National Prescribed Drug Registry. Participants were followed up for three years following their ...
More often prescribed as second-line therapy for dyslipidemia, ezetimibe is used in individuals with statin intolerance or those who failed to achieve the target LDL-C level on statin monotherapy. [ 26 ] [ 27 ] In particular, ezetimibe and statin dual therapy have shown a 15% greater LDL-C decrease compared with same-dose statins alone ...