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Type 2 statins Statins that are fully synthetic and have larger groups linked to the HMG-like moiety are often referred to as type 2 statins. One of the main differences between the type 1 and type 2 statins is the replacement of the butyryl group of type 1 statins by the fluorophenyl group of type 2 statins.
Statins remain a first-line treatment in familial hypercholesterolemia, [54] although other cholesterol-reducing measures may be required. [56] In people with homozygous deficiencies, statins may still prove helpful, albeit at high doses and in combination with other cholesterol-reducing medications.
The first statin drug available to the general public was lovastatin. Mevastatin has since been derivatized to the compound pravastatin, which is a pharmaceutical used in the lowering of cholesterol and preventing cardiovascular disease. In vitro, it has antiproliferative properties. [4]
In 1994, the findings of a Merck-funded study were published in The Lancet concluding the efficacy of statins in lowering cholesterol proving for the first time not only that a "statin reduced 'bad' LDL cholesterol but also that it led to a sharp drop in fatal heart attacks among people with heart disease." [112] [116]
The answer to that question lies in the anti-inflammatory effects of statins, which are prescribed to reduce cholesterol, but do more than that. Statins are pleiotropic drugs, meaning that they ...
When are statins prescribed to prevent cardiovascular disease? ... Statins are also sometimes prescribed to help lower cholesterol ... eligible to take statins based on PREVENT equations were not ...
New, experimental drugs designed to drive down dangerous levels of cholesterol were shown to be safe and effective in two groundbreaking bodies of research presented Sunday at an annual meeting of ...
[8] [4] Findings from clinical studies were only reported in 1980. [9] One of them, mevastatin, was the first member of the statin class of drugs. Soon after, lovastatin, the first commercial statin, was found in the Aspergillus mold. Although mevastatin never became an approved drug, the mevastatin derivative pravastatin did.