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  2. Metformin - Wikipedia

    en.wikipedia.org/wiki/Metformin

    Metformin has acid dissociation constant values (pK a) of 2.8 and 11.5, so it exists very largely as the hydrophilic cationic species at physiological pH values. The metformin pK a values make it a stronger base than most other basic medications with less than 0.01% nonionized in blood.

  3. Metabolic acidosis - Wikipedia

    en.wikipedia.org/wiki/Metabolic_acidosis

    The Henderson–Hasselbalch equation mathematically describes the relationship between blood pH and the components of the bicarbonate buffering system: = + ⁡ [] [], where pK a ≈ 6.1. In clinical practice, the CO 2 concentration is usually determined via Henry's law from P aCO 2, the CO 2 partial pressure in arterial blood: [] = (/).

  4. When Is the Best Time to Take Metformin? - AOL

    www.aol.com/best-time-metformin-141700387.html

    There’s no best time to take metformin for weight loss or type 2 diabetes (or any other condition). But taking it at the same time each day can help you stay consistent and avoid missing or ...

  5. Acid dissociation constant - Wikipedia

    en.wikipedia.org/wiki/Acid_dissociation_constant

    The electron-withdrawing effect of the substituent makes ionisation easier, so successive pK a values decrease in the series 4.7, 2.8, 1.4, and 0.7 when 0, 1, 2, or 3 chlorine atoms are present. [49] The Hammett equation , provides a general expression for the effect of substituents.

  6. Metformin Can Help You Lose Weight Loss, But It Also Has ...

    www.aol.com/metformin-help-lose-weight-loss...

    2. Alleviates Hunger. Metformin improves how well your cells respond to insulin. This helps regulate your blood sugar levels and manage spikes in insulin that can trigger hunger and food cravings.

  7. Pyruvate kinase - Wikipedia

    en.wikipedia.org/wiki/Pyruvate_kinase

    Metformin, or dimethylbiguanide, is the primary treatment used for type 2 diabetes. Metformin has been shown to indirectly affect pyruvate kinase through the inhibition of gluconeogenesis. Specifically, the addition of metformin is linked to a marked decrease in glucose flux and increase in lactate/pyruvate flux from various metabolic pathways.

  8. Protein pKa calculations - Wikipedia

    en.wikipedia.org/wiki/Protein_pKa_calculations

    From the titration of protonatable group, one can read the so-called pK a 12 which is equal to the pH value where the group is half-protonated (i.e. when 50% such groups would be protonated). The pK a 12 is equal to the Henderson–Hasselbalch pK a (pK HH a) if the titration curve follows the Henderson–Hasselbalch equation. [14]

  9. Trump Cabinet picks: Here’s who’s on the list to carry out ...

    www.aol.com/trump-cabinet-picks-list-carry...

    President-elect Trump has assembled his Cabinet, and senior staff positions are filling up for his second term in the White House before taking office in January. Trump has nominated leaders for ...

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