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Through lines of D1 receptor mutant mice, it had also been implicated in mediating both the locomotor sensation and rewarding effects of cocaine. Acute cocaine injections induced c-fos and CREB expression via D1 receptors and repeat cocaine administration, which is associated with long lasting AP-1 transcription complexes containing ΔFosB ...
The effect of these structural changes on behavior is uncertain and studies have produced conflicting results. Two studies [18] [19] have shown that an increase in dendritic spine density due to cocaine exposure facilitates behavioral sensitization, while two other studies [20] [21] produce contradicting evidence.
Extracting bone marrow from larger bones is easier than smaller bones. [14] Forensic toxicologists often use bone marrow to find what type poisons used, which can include cocaine or ethanol. [ 15 ] Ethanol specifically is one of the most abused drugs worldwide, be it through alcohol consumption and abuse being a leading cause in death.
Cocaine is a relatively "balanced" inhibitor, although facilitation of dopaminergic neurotransmission is what has been linked to the reinforcing and addictive effects. In addition, cocaine has some serious limitations in terms of its cardiotoxicity [188] due to its local anesthetic activity. Thousands of cocaine users are admitted to emergency ...
Cocaine (from French cocaïne, from Spanish coca, ultimately from Quechua kúka) [13] is a tropane alkaloid that acts as a central nervous system (CNS) stimulant.As an extract, it is mainly used recreationally and often illegally for its euphoric and rewarding effects.
How does pink cocaine affect someone? It can be hard to determine how the drug cocktail may affect someone after ingesting it. WebMD said this is due to several factors: the types of drugs mixed ...
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Chemical structure of cocaine. The biosynthesis of cocaine has long attracted the attention of biochemists and organic chemists. This interest is partly motivated by the strong physiological effects of cocaine, but a further incentive was the unusual bicyclic structure of the molecule. The biosynthesis can be viewed as occurring in two phases ...