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Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome is a medical condition, typically occurring in young children, in which high fever occurs periodically at intervals of about 3–5 weeks, frequently accompanied by aphthous-like ulcers, pharyngitis and cervical adenitis (cervical lymphadenopathy). The syndrome was described ...
The term lymphadenopathy strictly speaking refers to disease of the lymph nodes, [1] though it is often used to describe the enlargement of the lymph nodes. Similarly, the term lymphadenitis refers to inflammation of a lymph node, but often it is used as a synonym of lymphadenopathy. Cervical lymphadenopathy is a sign or a symptom, not a diagnosis.
Cervical lymphadenopathy is seen in 50% to 75% of children, whereas the other features are estimated to occur in 90%, [16] [24] but sometimes it can be the dominant presenting symptom. [30] [33] According to the diagnostic criteria, at least one impaired lymph node ≥ 15 mm in diameter should be involved. [32]
The term 'cervical' refers to the cervical lymph nodes in the neck; it is unrelated to the cervix. The alternative name scrofula comes from the medieval Latin scrōfula , diminutive of scrōfa , meaning brood sow , because swine were supposed to be subject to the complaint, [ citation needed ] or because the line of elevated lymph nodes was ...
Lymphadenopathy or adenopathy is a disease of the lymph nodes, in which they are abnormal in size or consistency. Lymphadenopathy of an inflammatory type (the most common type) is lymphadenitis , [ 1 ] producing swollen or enlarged lymph nodes.
Children often have generalized lymphadenopathy of the head and neck, or even PGL, without the finding of a sinister cause. At puberty this usually disappears. The immune system of some people may be sensitized by exposure to a living exogenous irritant such as a bacterial or viral infection , which then results in PGL after the organism has ...
The tonsils and cervical lymph nodes in these cases are hyperplasic and contain mixtures of normal-appearing lymphocytes, activated lymphocytes, plasma cells, and Reed–Sternberg-like cells. [16] Many of these normal-appearing and activated B cells and a small percentage of the tissue's T and NK cells are EBV+ with the virus being mostly in ...
Any joint, including the temporomandibular joints, [11] cervical spine, [12] hips, [13] and tiny joints of the hands and feet, may be impacted. Myalgia and tenosynovitis are two other typical musculoskeletal symptoms. [9] SJIA is characterized by splenic and lymph node enlargements, which can happen separately or simultaneously.